{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:48:36Z","timestamp":1761742116052},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,7,3]],"date-time":"2002-07-03T00:00:00Z","timestamp":1025654400000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold> Combined immunosuppression therapy and acute rejection surveillance after heart transplantation may influence clinical outcome. This prospective, longitudinal study investigated 27 pediatric patients (12\u2003days to 12\u2003yr of age; mean 3.0\u2003yr) who underwent a post\u2010operative regimen that included long\u2010term treatment with cyclosporin A and azathioprine (double immunosuppression) and polyclonal anti\u2010thymocyte serum induction therapy. Non\u2010invasive parameters were used to diagnose acute rejection. The actuarial survival, clinical outcomes, and complications were analyzed. The actuarial survival after double immunosuppression and induction therapy with polyclonal anti\u2010thymocyte serum was 89%, 73%, and 57% at 1, 4, and 8\u2003yr, respectively. The rejection frequency was 2.6 episodes\/patient and the infection frequency, 3.7 episodes\/patient. One year after transplantation, systemic arterial hypertension was detected in 21% of patients. Hence, double immunosuppression with polyclonal anti\u2010thymocyte serum induction therapy combined with surveillance of acute rejection with non\u2010invasive tests may provide promising clinical outcome in pediatric heart transplant recipients.<\/jats:p>","DOI":"10.1034\/j.1399-3046.2002.01075.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T18:59:08Z","timestamp":1047495548000},"page":"208-213","source":"Crossref","is-referenced-by-count":11,"title":["Eight\u2010year experience of pediatric heart transplantation: Clinical outcome using \u2028non\u2010invasive methods for the evaluation \u2028of acute rejection"],"prefix":"10.1034","volume":"6","author":[{"given":"Estela","family":"Azeka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Barbero","family":"Marcial","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Jatene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Jos\u00e9 Ot\u00e1vio Costa","family":"Auler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ant\u00f4nio Franchini","family":"Ramires","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,7,3]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1001\/jama.1985.03360230053022","article-title":"Baboon\u2010to\u2010human cardiac xenotransplantation in a neo\u2010nate","volume":"254","author":"Bailey LL","year":"1985","journal-title":"JAMA"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(00)00243-6"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(99)00114-X"},{"key":"e_1_2_8_5_2","first-page":"691","article-title":"The registry of the International Society of Heart and Lung Transplantation: fourteenth official report \u2013 1997","volume":"16","author":"Hosenpud JF","year":"1997","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.10.1262"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00006-7"},{"key":"e_1_2_8_8_2","first-page":"145","article-title":"Pediatric heart transplantation at Loma Linda: 1985 to 1996","volume":"10","author":"Chinnock RE","year":"1996","journal-title":"Clin Transpl"},{"key":"e_1_2_8_9_2","first-page":"S255","article-title":"Rejection management and long\u2010term surveillance of the pediatric heart transplant recipient: the Loma Linda experience","volume":"12","author":"Chinnock RE","year":"1993","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(00)00080-2"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90814-H"},{"key":"e_1_2_8_12_2","first-page":"230","article-title":"Neoplastic disorders after pediatric heart transplantation","volume":"88","author":"Bernstein D","year":"1993","journal-title":"Circulation"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70173-2"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1058-9813(00)00044-8"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60276-8"},{"key":"e_1_2_8_16_2","first-page":"S195","article-title":"Surgical intervention in children after heart transplantation","volume":"12","author":"Razzouk AJ","year":"1993","journal-title":"J Heart Lung Transplant"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1399-3046.2002.01075.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1399-3046.2002.01075.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T20:12:02Z","timestamp":1697573522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1399-3046.2002.01075.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1034\/j.1399-3046.2002.01075.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1399-3046.2002.01075.x","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6]]}}}