{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T09:50:19Z","timestamp":1761126619727},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,1,15]],"date-time":"2003-01-15T00:00:00Z","timestamp":1042588800000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold> Systemic scedosporiasis due to the anamorph or asexual form <jats:italic>Scedosporium apiospermum<\/jats:italic> (<jats:italic>Pseudallescheria boydii<\/jats:italic>) has become an important cause of opportunistic mycosis, especially in patients undergoing high\u2010risk hematopoietic stem cell transplantation. We report a case of rapidly progressive cerebellar hyalohyphomycosis due to <jats:italic>Scedosporium apiospermum<\/jats:italic> in an allogeneic marrow graft recipient receiving treatment for severe graft\u2010versus\u2010host disease. This fatal breakthrough intracranial abscess, due to amphotericin B\u2010resistant (minimum inhibitory concentration &gt;\u200316\u2003\u00b5g\/ml) mold, developed during the course of systemic antifungal therapy given for multicentric pulmonary aspergillosis. Despite treatment with high\u2010dose Abelcet<jats:sup>\u00ae<\/jats:sup> (10\u2003mg\/kg daily), free amphotericin B was not detected in postmortem cerebellar tissue. A broad\u2010spectrum triazole\u2010based agent (voriconazole\/UK\u2010109,\u2003496 \u2013 Vfend<jats:sup>\u00ae<\/jats:sup>), and a novel fungal cell wall inhibitor, an echinocandin\/pneumocandin analog (caspofungin\/MK\u20100991 \u2013 Cancidas<jats:sup>\u00ae<\/jats:sup>), which exhibit excellent <jats:italic>in vitro<\/jats:italic> activity against most clinical <jats:italic>Pseudallescheria boydii<\/jats:italic>\u2013<jats:italic>Scedosporium apiospermum<\/jats:italic> isolates, have recently become available in the United States and may provide much needed treatment options for patients at risk.<\/jats:p>","DOI":"10.1034\/j.1399-3062.2002.02008.x","type":"journal-article","created":{"date-parts":[[2010,11,17]],"date-time":"2010-11-17T11:50:15Z","timestamp":1289994615000},"page":"212-217","source":"Crossref","is-referenced-by-count":41,"title":["Breakthrough <i>Scedosporium apiospermum<\/i> (<i>Pseudallescheria boydii<\/i>) brain abscess during therapy for invasive pulmonary aspergillosis following high\u2010risk allogeneic hematopoietic stem cell transplantation. Scedosporiasis and recent advances in antifungal therapy"],"prefix":"10.1111","volume":"4","author":[{"given":"A.","family":"Safdar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.B.","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.W.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,1,15]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90255-6"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/319985"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709371"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2000.020405.x"},{"key":"e_1_2_4_6_2","first-page":"332","article-title":"Disseminated infection due to Scedosporium apiospermum in liver transplantation. 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