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In particular, when therapy started before the age of 20 years, the rates of either one of these complications were as high as 80%. Surprisingly, these reports have been relatively ignored in the psychiatric literature to date. As increasing numbers of bipolar patients are in long\u2010term treatment with valproate, there is an important need for further research that clarifies the relationship between long\u2010term administration of valproate and other mood stabilizers and the potential development of reproductive endocrinologic abnormalities, and for increased awareness among clinicians and patients of the unknown potential for these worrisome side\u2010effects.<\/jats:p>","DOI":"10.1034\/j.1399-5618.2000.020105.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T04:48:12Z","timestamp":1047358092000},"page":"37-41","source":"Crossref","is-referenced-by-count":10,"title":["Valproate treatment and the risk of hyperandrogenism and polycystic ovaries"],"prefix":"10.1111","volume":"2","author":[{"given":"Jair 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