{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:54:26Z","timestamp":1761486866769},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,9,25]],"date-time":"2002-09-25T00:00:00Z","timestamp":1032912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Gabapentin (GBP) may be useful in bipolar disorders, including as adjunctive therapy for bipolar depression, although controlled studies suggest inefficacy as primary treatment for mania or treatment\u2010resistant rapid cycling.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We performed a 12\u2010week trial of open GBP (mean dose 1725\u2003mg\/day) added to stable doses of mood stabilizers or atypical antipsychotics in 22 (10 women, mean age 38.4\u2003years) depressed [28\u2010item Hamilton Depression Rating Scale (HDRS) &gt;18] bipolar (10 bipolar I, 12 bipolar II) disorder outpatients. Mean illness duration was 18.6\u2003years; current depressive episode duration was 18.0\u2003weeks. Prospective 28\u2010item HDRS, Young Mania Rating Scale (YMRS) and Clinical Global Impression \u2013 Severity (CGI\u2010S) ratings were obtained.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Overall, HDRS ratings decreased 53% from 32.5\u2003\u00b1\u20037.7 at baseline to 16.5\u2003\u00b1\u200312.8 at week 12 (p\u2003&lt;\u20030.0001). Twelve of 22 (55%) patients had moderate to marked improvement (HDRS decrease=50%) with HDRS decreasing 78% from 27.9\u2003\u00b1\u20036.2 to 6.2\u2003\u00b1\u20034.5 (p\u2003&lt;\u20030.0001). Eight of 22 (36%) patients remitted (HDRS\u22658). In non\u2010responders, HDRS decreased from 38.0\u2003\u00b1\u20035.4 to 28.9\u2003\u00b1\u20036.7 (p=0.005). Ten of 13 (77%) mild to moderately depressed (baseline HDRS &gt;18 and &lt;35) patients responded, while only two of nine patients (22%) with severe depression (HDRS\u2003?\u200335) responded (p\u2003&lt;\u20030.03). Both groups, however, had similar, statistically significant HDRS decreases. GBP was well tolerated.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Open adjunctive GBP was effective and well tolerated in patients with mild to moderate bipolar depression. 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