{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:15:21Z","timestamp":1783440921255,"version":"3.54.6"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,2,12]],"date-time":"2003-02-12T00:00:00Z","timestamp":1045008000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:p>Atypical antipsychotics are now commonly used in the treatment of bipolar disorder, as they have been shown to have effects on mania as well as psychosis. Shortly after the introduction of atypical antipsychotics, several cases of associated hypomania and mania were reported. Ziprasidone is an atypical antipsychotic recently approved by the Food and Drug Administration for the treatment of psychosis. Although ziprasidone has also been shown to be effective in treating mania, it may be associated with the induction of mania or hypomania. We report four cases of mania associated with initiation of ziprasidone, which, to our knowledge, are the first reported for this drug in bipolar patients. As ziprasidone has substantial serotonergic and noradrenergic action, we hypothesize, it may more likely induce mania than other atypical antipsychotics. We advocate future studies to evaluate ziprasidone's efficacy in treating bipolar disorder and caution clinicians that induction of mania or hypomania may be possible with this agent.<\/jats:p>","DOI":"10.1034\/j.1399-5618.2003.02258.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T04:51:03Z","timestamp":1047358263000},"page":"72-75","source":"Crossref","is-referenced-by-count":23,"title":["Ziprasidone\u2010associated mania: a case series and review of the mechanism"],"prefix":"10.1111","volume":"5","author":[{"given":"CF","family":"Baldassano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ballas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SM","family":"Datto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Littman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"O'Reardon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA","family":"Rynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,2,12]]},"reference":[{"key":"e_1_2_8_2_2","unstructured":"SachsGS PrintzDJ KahnDA CarpenterD DochertyJP.Medication treatment of bipolar disorder.Postgraduate Medicine Special Report 2000."},{"key":"e_1_2_8_3_2","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1176\/ajp.156.5.702","article-title":"Olanzapine versus placebo in the treatment of acute mania. Olanazapine HGEH Study Group","volume":"156","author":"Tohen M","year":"1999","journal-title":"Am J Psychaitry"},{"key":"e_1_2_8_4_2","first-page":"176","article-title":"Risperidone compared with both lithium and haloperidol in mania: a double\u2010blind randomized controlled trial","volume":"21","author":"Segal J","year":"1998","journal-title":"Clin Neuropharmacol"},{"key":"e_1_2_8_5_2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1177\/070674379704200211","article-title":"Acute treatment of bipolar disorder with adjunctive risperidone in outpatients","volume":"42","author":"Ghaemi SN","year":"1997","journal-title":"Can J Psychiatry"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2000.020307.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1176\/ajp.156.7.1114","article-title":"Olanzapine\u2010induced mania","volume":"156","author":"Fitz\u2010Gerald MJ","year":"1999","journal-title":"Am J Psychiatry"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.18153"},{"key":"e_1_2_8_9_2","first-page":"174","article-title":"Probable induction of mania by risperidone","volume":"57","author":"Koek RJ","year":"1996","journal-title":"J Cin Psychiatry"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199802000-00002"},{"key":"e_1_2_8_11_2","first-page":"649","article-title":"Possible induction of mania and hypomania by olanzapine or risperdone: a critical review of reported cases","volume":"61","author":"Aubry J\u2010M","year":"2000","journal-title":"Am J Psychiatry"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(98)00090-6"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199612000-00003"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.8.1130"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.4.673"},{"key":"e_1_2_8_16_2","doi-asserted-by":"crossref","unstructured":"KeckP IceK.A 3\u2010week double\u2010blind randomized trial of ziprasidone in the acute treatment of mania.Poster 40th Annual New Clinical Drug Evaluation Unit Meeting (NCDEU) 2001.","DOI":"10.1016\/S0924-977X(00)80328-4"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v59n0207f"},{"key":"e_1_2_8_18_2","first-page":"2177","article-title":"The novel antipsychotic ziprasidone has a unique human receptor binding profile compared to other agents","volume":"24","author":"Schmidt AW","year":"1998","journal-title":"Soc Neurosci Abstract"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.01790220086014"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.143.2.260a"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0609"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1399-5618.2003.02258.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1399-5618.2003.02258.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T22:57:55Z","timestamp":1697237875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1399-5618.2003.02258.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["10.1034\/j.1399-5618.2003.02258.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1399-5618.2003.02258.x","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,2]]}}}