{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T13:39:16Z","timestamp":1772717956496,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":541,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Hyperventilation during sevoflurane\u2010N<jats:sub>2<\/jats:sub>O\u2010O<jats:sub>2<\/jats:sub> mask induction in adults is associated with a hyperdynamic circulatory response and epileptiform electroencephalogram (EEG). We tested the hypothesis that delaying onset of hyperventilation will prevent severe (periodic) epileptiform EEG and hyperdynamic response.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty patients were randomized to receive either delayed (group D, n=15) or immediate (group I, n=15) onset of hyperventilation during sevoflurane (8% in N<jats:sub>2<\/jats:sub>O 50%) mask inhalation induction with single\u2010breath method for unconsciousness. Fifteen patients were allowed to breathe spontaneously for 2 min after loss of consciousness and controlled hyperventilation (ETCO<jats:sub>2<\/jats:sub> &lt;4%) was started thereafter. In 15 patients controlled hyperventilation was started immediately after loss of consciousness. EEG was recorded, and mean arterial pressure (MAP) and heart rate (HR) registered.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Epileptiform EEG patterns were seen in 13 patients in group I and in 9 patients in group D (n.s.). Periodic epileptiform discharges (PED) tended to occur more often in group I (<jats:italic>P<\/jats:italic>=0.07). Heart rate and MAP were higher in group I than in group D from 2 min to 3 min (<jats:italic>P<\/jats:italic>&lt;0.05), and both HR and MAP rose significantly from the baseline in group I. In group D, HR but not MAP rose significantly from baseline.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Regardless of its timing, hyperventilation at a high sevoflurane concentration produced severe epileptiform EEG with a hyperdynamic response. PED tended to occur more often with immediate onset of hyperventilation (\n\t\t\t\t\t<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#fn1\"><jats:sup>Note<\/jats:sup><\/jats:ext-link>).<\/jats:p>","DOI":"10.1034\/j.1399-6576.2000.440609.x","type":"journal-article","created":{"date-parts":[[2003,3,10]],"date-time":"2003-03-10T09:42:17Z","timestamp":1047289337000},"page":"713-719","source":"Crossref","is-referenced-by-count":44,"title":["Epileptiform EEG during sevoflurane mask induction: Effect of delaying the onset of hyperventilation"],"prefix":"10.1111","volume":"44","author":[{"given":"A.","family":"Vakkuri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"J\u00e4ntti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"S\u00e4rkel\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lindgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Korttila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Yli\u2010Hankala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199906000-00034"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199912000-00009"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-197205000-00007"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1975.tb05197.x"},{"key":"e_1_2_6_6_2","first-page":"269","volume-title":"Current 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