{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:26:32Z","timestamp":1763745992421},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":449,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:sec><jats:title>Purpose:<\/jats:title><jats:p>The aim of the study was to investigate whether preoperative infiltration with ropivacaine in conjunction with breast surgery improves postoperative pain management and attenuates postoperative nausea and vomiting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p>Prospective, randomised, double\u2010blind study, including 60 healthy women (ASA 1\u20132) allocated to one of two groups. Thirty patients were given 0.3 ml\/kg saline in the operating field before surgery. Another 30 patients received a similar volume of ropivacaine 3.75 mg\/ml. A visual analogue scale (0\u2013100 mm) was used for evaluation of postoperative pain, nausea and vomiting. If the score was more than 30 mm at rest, the patients were given ketobemidone i.v. as treatment for postoperative pain, and dixyrazine i.v. against nausea and vomiting. The intra\u2010 and postoperative analgesic requirements and postoperative nausea and vomiting were registered.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The intraoperative fentanyl consumption was similar in the saline group 81\u00b122 \u03bcg vs 76\u00b128 \u03bcg; (ns) in the ropivacaine group. The postoperative 24\u2010h ketobemidone consumption was also similar to those treated with ropivacaine (4.2\u00b12.6 mg vs 4.2\u00b14.3 mg; ns). Postoperative nausea and vomiting (PONV) occurred with similar frequencies in both groups. The 24\u2010h dixyrazine consumption was the same in the two groups (2.1\u00b12.7 mg in the saline group compared to 2.4\u00b12.8 mg in the ropivacaine group; ns). After 6 h recovery, 41% of all patients had experienced nausea and 20% vomiting.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> We found no differences in postoperative pain management between 3.75 mg\/ml ropivacaine and saline wound infiltration before breast surgery. The data show similar postoperative needs of analgesics and antiemetics with a similar frequency of PONV.<\/jats:p><\/jats:sec>","DOI":"10.1034\/j.1399-6576.2000.440910.x","type":"journal-article","created":{"date-parts":[[2003,3,10]],"date-time":"2003-03-10T09:43:48Z","timestamp":1047289428000},"page":"1093-1098","source":"Crossref","is-referenced-by-count":29,"title":["Preoperative ropivacaine infiltration in breast surgery"],"prefix":"10.1111","volume":"44","author":[{"given":"A.","family":"Johansson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Axelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ingvar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010H.","family":"Luttropp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lundberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1987.tb02612.x"},{"key":"e_1_2_6_3_2","first-page":"213","article-title":"Is wound infiltration with anaesthetic effective as pre\u2010emptive analgesia? 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