{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T10:40:04Z","timestamp":1697539204633},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2009,8,12]],"date-time":"2009-08-12T00:00:00Z","timestamp":1250035200000},"content-version":"vor","delay-in-days":2476,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Local effects of dopexamine on intestinal vascular tone and oxygenation were investigated during intestinal hypotension. To this end, we employed an experimental model, in which the superior mesenteric arterial pressure (P<jats:sub>SMA<\/jats:sub>) was controlled by an adjustable perivascular clamp. This approach enabled us to keep the intestinal perfusion pressure (IPP) constant in the face of any systemic circulatory alterations.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> In 11 barbiturate\u2010anesthetized pigs, we instrumented the superior mesenteric circulation for assessments of vascular resistance (R<jats:sub>MES<\/jats:sub>), IPP, jejunal mucosal perfusion (Laser Doppler) and intestinal tissue oxygenation (microoximetry). Measurements were carried out before and during dopexamine infusions (0.5 and 1.0\u2003\u00b5g\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>) at a freely variable P<jats:sub>SMA<\/jats:sub> (i.e. the perivascular clamp fully open) and at a P<jats:sub>SMA<\/jats:sub> of 50\u2003mmHg and 30\u2003mmHg.<\/jats:p><jats:p><jats:bold>Results:<jats:italic>\u2003<\/jats:italic><\/jats:bold> At a constant P<jats:sub>SMA<\/jats:sub> of 50\u2003mmHg, dopexamine had no significant intestinal vascular effects. However, at a constant P<jats:sub>SMA<\/jats:sub> of 30\u2003mmHg, both doses of dopexamine were associated with decreases in R<jats:sub>MES.<\/jats:sub> Effects of dopexamine on intestinal oxygen delivery and extraction were minimal during these procedures, while a minor decrease in intestinal tissue oxygen tension was observed during dopexamine administration at the lowest IPP level.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> At very low intestinal perfusion pressures (approximately 30\u2003mmHg) dopexamine produces intestinal vasodilation in excess of what is produced by intrinsic autoregulation. This suggests that there is a vasodilatory reserve in the intestine under such conditions and that a pharmacological vasodilator like dopexamine may improve intestinal circulation during regional severe hypotension.<\/jats:p>","DOI":"10.1034\/j.1399-6576.2002.461009.x","type":"journal-article","created":{"date-parts":[[2003,3,10]],"date-time":"2003-03-10T09:48:45Z","timestamp":1047289725000},"page":"1217-1226","source":"Crossref","is-referenced-by-count":1,"title":["Does dopexamine influence regional vascular tone and oxygenation during intestinal 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