{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T15:02:51Z","timestamp":1700319771537},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":2462,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:p><jats:bold>Aims.<\/jats:bold> 1. Ascertain antenatal and intrapartum risk factors for term neonates ventilated primarily for \u2018perinatal asphyxia\u2019. 2. Describe the neonatal morbidity and mortality.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> Population\u2010based case control cohort study.<\/jats:p><jats:p> <jats:italic>Setting.<\/jats:italic> Sydney and four large rural\/urban health areas in New South Wales.<\/jats:p><jats:p> <jats:italic>Subjects.<\/jats:italic> Singleton term infants, no major congenital anomaly: subset of 83 infants ventilated primarily for \u2018asphyxia\u2019 from 182 cases admitted to a tertiary neonatal intensive care unit (NICU) for mechanical ventilation, 550 randomly selected controls.<\/jats:p><jats:p> <jats:italic>Outcome.<\/jats:italic> Risk factors for case status by maternal, antenatal, labor, delivery, and combined epochs, adjusted odds ratios (OR), 95 per cent confidence intervals (CI), <jats:italic>p<\/jats:italic>&lt;0.05.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Predictors of case status by multivariate epochs: Primigravida (1.8 [1.1, 2.8]), thyroid disease (7.8 [1.1, 57.0]), any antenatal complication (5.1 [3.0, 8.6]), growth restriction (4.2 [1.7, 10.4]), male gender (2.1 [1.3, 3.5]), gestational age &gt;40 weeks (1.9 (1.1, 3.3)), prolonged rupture of membranes (9.7 [1.3, 72.5]), complicated labor (6.6 [3.7, 11.9]), induced labor (2.2 [1.3, 3.9]), prostaglandins 2.46 [1.23, 4.91]), maternal pyrexia (10.8 [2.8, 42.7]), placental hemorrhage in labor (OR 4.24 [1.45, 12.42]), forceps delivery (4.1 [1.9, 8.5]), emergency cesarean section (4.7 [2.6, 8.7]). Twenty case infants (24%) and no control infants died.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> This study has shown maternal and antepartum risk factors for severe neonatal morbidity in term infants. More centers need to become interested in the term baby, so that a larger multicenter study can further elucidate the heterogeneous causal pathways to term neonatal morbidity.<\/jats:p>","DOI":"10.1034\/j.1600-0412.2001.801007.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T03:01:16Z","timestamp":1047351676000},"page":"905-916","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Do very sick neonates born at term have antenatal risks?"],"prefix":"10.1111","volume":"80","author":[{"given":"Lee","family":"Sutton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey P.","family":"Sayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Bajuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"Berry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Henderson\u2010Smart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7172.1549"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6981.681"},{"key":"e_1_2_8_4_2","unstructured":"Report of the New South Wales Neonatal Intensive Care Unit Study (NICUS) 1992 cohort. 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