{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:04:45Z","timestamp":1759565085231},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,2,12]],"date-time":"2003-02-12T00:00:00Z","timestamp":1045008000000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p> <jats:italic>Acta Obstet Gynecol Scand<\/jats:italic> 2003; 82: 28\u201332. \u00a9 Acta Obstet Gynecol Scand 2003<\/jats:p><jats:p><jats:bold>Background.\u2003<\/jats:bold> Cord blood thyroid\u2010stimulating hormone level is elevated among neonates who undergo more perinatal stress. The aim of this study was to investigate the effect of twin pregnancy on the cord blood thyroid\u2010stimulating hormone level.<\/jats:p><jats:p><jats:bold>Methods.\u2003<\/jats:bold> The study group consisted of 24\u2003910 singleton and 543 twin neonates over a 4\u2010year period. The effect of twin pregnancy on the cord blood thyroid\u2010stimulating level was evaluated. Linear regression analysis was used to control for the effect of mode of delivery, birth weight, and infant sex.<\/jats:p><jats:p><jats:bold>Results.\u2003<\/jats:bold> The median cord blood thyroid\u2010stimulating hormone levels (interquartile range) in the singletons and in the twins were 5.8mIU\/l (4.2\u20138.6) and 5.6mIU\/l (4.3\u20137.5), respectively. Linear regression analysis revealed no significant difference between singleton and twin cord blood thyroid\u2010stimulating hormone levels (<jats:italic>p =<\/jats:italic> 0.23). Cord thyroid\u2010stimulating hormone levels tended to be higher in second\u2010born twins (<jats:italic>p =<\/jats:italic> 0.08) and monochorionic twins (<jats:italic>p =<\/jats:italic> 0.097) compared with singleton neonates. Twins with more than 20% weight discordance were associated with a significantly higher cord blood thyroid\u2010stimulating hormone level (<jats:italic>p =<\/jats:italic> 0.035).<\/jats:p><jats:p><jats:bold>Conclusion.\u2003<\/jats:bold> Cord blood thyroid\u2010stimulating hormone level is elevated in some subgroups of twins who are at higher risk of adverse perinatal outcomes. However, the overall effect of multiple pregnancy on the cord blood thyroid\u2010stimulating hormone level is small. Cord blood thyroid\u2010stimulating hormone screening for congenital hypothyroidism is also valid in twin pregnancies.<\/jats:p>","DOI":"10.1034\/j.1600-0412.2003.820105.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T03:05:23Z","timestamp":1047351923000},"page":"28-31","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cord blood thyroid\u2010stimulating hormone level in twin pregnancy"],"prefix":"10.1111","volume":"82","author":[{"given":"Louis Yik\u2010Si","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pui Yu","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tze Kin","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,2,12]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"AuthorA.Special problems of multiple gestation.ACOG Educational Bulletin1998:253."},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199712000-00011"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/oxfordjournals.aje.a115852","article-title":"Comparison of infant mortality among twins and singleton. United States 1960\u201383","volume":"15","author":"Kleinman JC","year":"1991","journal-title":"Am J Epidemiol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb10948.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00290-8"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)01111-X"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90670-2"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(87)90201-8"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000293779"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(85)90150-9"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/080352599750029277"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)92159-0"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2001.801108.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(92)90004-Z"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(88)90619-5"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1987.tb01159.x"},{"key":"e_1_2_5_18_2","first-page":"701","article-title":"Thyroid function in small for gestational age fetuses","volume":"77","author":"Thrope\u2010Beeston JG","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(94)00455-M"},{"key":"e_1_2_5_20_2","first-page":"436","article-title":"A comparison of pre\u2010discharge survival and morbidity in singleton and twin very low birth weight infants","volume":"80","author":"Wolf EJ","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70334-X"},{"key":"e_1_2_5_22_2","first-page":"826","article-title":"Umbilical cord blood gas assessment of twins","volume":"75","author":"Brown HL","year":"1990","journal-title":"Obstet Gynecol"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0412.2003.820105.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0412.2003.820105.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0412.2003.820105.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T20:24:31Z","timestamp":1697228671000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0412.2003.820105.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1034\/j.1600-0412.2003.820105.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0412.2003.820105.x","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]},"assertion":[{"value":"2003-02-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}