{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:39:54Z","timestamp":1775687994395,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":510,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p> <jats:bold>Objective: <\/jats:bold>Recent case studies suggest that impaired granulopoiesis, well\u2010known to occur during clozapine treatment, may also be observed when olanzapine is administered. The underlying mechanisms are unknown, but haematopoietic cytokines such as granulocyte colony\u2010stimulating factor (G\u2013CSF) are likely to be involved.<\/jats:p><jats:p> <jats:bold>Method: <\/jats:bold>We measured the plasma levels of G\u2013CSF and of other cytokines longitudinally in a female patient who developed granulocytopenia twice, first during clozapine treatment and again when olanzapine was administered.<\/jats:p><jats:p> <jats:bold>Results: <\/jats:bold>G\u2013CSF levels, but not those of other cytokines, closely paralleled granulocyte counts, yielding a significant positive correlation. G\u2013CSF was not detectable in plasma when granulocytopenia occurred. Granulocytopenia resolved spontaneously despite continuing treatment with olanzapine.<\/jats:p><jats:p> <jats:bold>Conclusion: <\/jats:bold>The present case suggests that clozapine and olanzapine both are able to induce transient granulocytopenia through a similar or common mechanism that does not involve a compensatory increase in G\u2013CSF levels.<\/jats:p>","DOI":"10.1034\/j.1600-0447.2000.102002153.x","type":"journal-article","created":{"date-parts":[[2003,3,10]],"date-time":"2003-03-10T10:03:59Z","timestamp":1047290639000},"page":"153-155","source":"Crossref","is-referenced-by-count":30,"title":["Granulocyte colony\u2010stimulating factor plasma levels during clozapine\u2010 and olanzapine\u2010induced granulocytopenia"],"prefix":"10.1111","volume":"102","author":[{"given":"Andreas","family":"Schuld","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dunja","family":"Hinze\u2010Selch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Haack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Pollm\u00e4cher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0447.2000.102002153.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0447.2000.102002153.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0447.2000.102002153.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T09:29:38Z","timestamp":1698571778000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0447.2000.102002153.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["10.1034\/j.1600-0447.2000.102002153.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0447.2000.102002153.x","archive":["Portico"],"relation":{},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}