{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T18:43:11Z","timestamp":1783708991963,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T00:00:00Z","timestamp":1215388800000},"content-version":"vor","delay-in-days":2744,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p> <jats:bold>Objective:<\/jats:bold> \u2002This is the first study to investigate the Quality of Life (QOL) of patients with Gilles de la Tourette's Syndrome (GTS).<\/jats:p><jats:p> <jats:bold>Method:<\/jats:bold> \u2002One hundred and three out\u2010patients with GTS completed a semi\u2010structured interview and 90 of these completed questionnaires screening for depression, anxiety and obsessive\u2010compulsive behaviour. QOL was measured with the SF\u201036 and the Quality of Life Assessment Schedule (QOLAS).<\/jats:p><jats:p> <jats:bold>Results:<\/jats:bold> \u2002Patients with GTS showed significantly worse QOL than a general population sample. They had better QOL than patients with intractable epilepsy as measured by the QOLAS, although the SF\u201036 showed significant differences on the subscales Role Limitation due to physical problems and Social Functioning only. Factors influencing QOL domains were employment status, tic severity, obsessive\u2010compulsive behaviour, anxiety and depression.<\/jats:p><jats:p> <jats:bold>Conclusion:<\/jats:bold> \u2002QOL is impaired in patients with GTS. Measurement of QOL could be used alongside conventional measurements to assess benefit of treatment. We recommend the QOLAS and SF\u201036 be used.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2001.00147.x","type":"journal-article","created":{"date-parts":[[2010,8,17]],"date-time":"2010-08-17T11:41:55Z","timestamp":1282045315000},"page":"52-59","source":"Crossref","is-referenced-by-count":213,"title":["Quality of Life (QOL) of patients with Gilles de la Tourette's syndrome"],"prefix":"10.1111","volume":"103","author":[{"given":"K.","family":"Elstner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. E.","family":"Selai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Trimble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,7]]},"reference":[{"key":"e_1_2_7_2_2","volume-title":"Diagnostic and statistical manual of mental disorders, 4th edn (DSM\u2010IV)","author":"American Psychiatric Association (APA)","year":"1994"},{"key":"e_1_2_7_3_2","volume-title":"International classification of diseases and health related problems, 10th revision","author":"World Health Organization","year":"1992"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.171.3.283"},{"key":"e_1_2_7_5_2","unstructured":"RobertsonMM.The relationship between Gilles de la Tourette\u2019s Syndrome and Obsessive Compulsive Disorder.J Serotonin Res1995(Suppl 1):49\u201362."},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1994.tb01209.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.152.3.383"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.154.2.147"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.162.1.114"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.8.3.311"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220317"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.74.12.1310"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/070674379504000109"},{"key":"e_1_2_7_14_2","first-page":"285","volume-title":"Gilles de la Tourette\u2019s Syn\u2010drome. Advances in neurology","author":"Asam U","year":"1982"},{"key":"e_1_2_7_15_2","first-page":"22","volume-title":"Gilles de la Tourette\u2019s Syndrome and related tic disorders","author":"Bruun RD","year":"1988"},{"key":"e_1_2_7_16_2","volume-title":"SF\u201036 Health survey manual and interpretation guide. Boston","author":"Ware JE","year":"1993"},{"key":"e_1_2_7_17_2","unstructured":"SelaiC TrimbleMR RossorMN&HarveyRJ.Assessing QOL in dementia: psychometric testing of the QOL Assess\u2010ment Schedule.Neuropsychol Rehab 2000 in press."},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-198907000-00015"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.133.8.944"},{"key":"e_1_2_7_20_2","unstructured":"FransellaF&BannisterD.A manual for repertory grid technique.London: Academic Press Harcourt Brace Jovanovich Publishers1977."},{"key":"e_1_2_7_21_2","first-page":"151","volume-title":"Epilepsy and QOL","author":"Kendrick AM","year":"1994"},{"key":"e_1_2_7_22_2","first-page":"1","article-title":"Adjunctive therapy in epilepsy with new antiepileptic drugs: is it of any value?","volume":"7","author":"Selai C","year":"1988","journal-title":"Seizure"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(99)00075-3"},{"key":"e_1_2_7_24_2","first-page":"123","volume-title":"Assess\u2010ment of depression","author":"Steer RA","year":"1982"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700039714"},{"key":"e_1_2_7_26_2","volume-title":"Manual for the state\u2010trait anxiety inventory","author":"Spielberger CD","year":"1983"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1981.01780260035003"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700030816"},{"key":"e_1_2_7_29_2","volume-title":"SPSS base system user's guide","author":"SPSS Inc","year":"1993"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/10673229709034730"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.11.1593"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6846.160"},{"key":"e_1_2_7_33_2","volume-title":"General household survey 1993","author":"Office of Population Census & Surveys","year":"1995"},{"key":"e_1_2_7_34_2","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1001\/jama.1989.03430070062031","article-title":"The functional status and well\u2010being of patients with chronic conditions: results from the Medical Outcome Study","volume":"262","author":"Wells KB","year":"1989","journal-title":"JAMA"},{"key":"e_1_2_7_35_2","unstructured":"SelaiCE&TrimbleMR.The Quality of Life Assessment Schedule (QOLAS): user guide. London: Institute of Neuro\u2010logy The National Hospital Queen Square University College London1999."}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0447.2001.00147.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0447.2001.00147.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T19:00:51Z","timestamp":1697569251000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0447.2001.00147.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":34,"aliases":["10.1034\/j.1600-0447.2001.00147.x","10.1034\/j.1600-0447.2001.00147.x"],"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["10.1111\/j.1600-0447.2001.00147.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0447.2001.00147.x","archive":["Portico"],"relation":{},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}