{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:49:11Z","timestamp":1763765351347},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,8,28]],"date-time":"2002-08-28T00:00:00Z","timestamp":1030492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p>Puri BK, Counsell SJ, Zaman R, Main J, Collins AG, Hajnal JV, Davey NJ. Relative increase in choline in the occipital cortex in chronic fatigue syndrome. Acta Psychiatr Scand 2002: 106: 224\u2013226. \u00a9 Blackwell Munksgaard 2002.<\/jats:p><jats:p> <jats:bold>Objective:<\/jats:bold>\u2002To test the hypothesis that chronic fatigue syndrome (CFS) is associated with altered cerebral metabolites in the frontal and occipital cortices.<\/jats:p><jats:p> <jats:bold>Method:<\/jats:bold>\u2002Cerebral proton magnetic resonance spectroscopy (<jats:sup>1<\/jats:sup>H MRS) was carried out in eight CFS patients and eight age\u2010 and sex\u2010matched healthy control subjects. Spectra were obtained from 20\u2003\u00d7\u200320\u2003\u00d7\u200320\u2003mm<jats:sup>3<\/jats:sup> voxels in the dominant motor and occipital cortices using a point\u2010resolved spectroscopy pulse sequence.<\/jats:p><jats:p> <jats:bold>Results:<\/jats:bold>\u2002The mean ratio of choline (Cho) to creatine (Cr) in the occipital cortex in CFS (0.97) was significantly higher than in the controls (0.76; <jats:italic>P<\/jats:italic>=0.008). No other metabolite ratios were significantly different between the two groups in either the frontal or occipital cortex. In addition, there was a loss of the normal spatial variation of Cho in CFS.<\/jats:p><jats:p> <jats:bold>Conclusion:<\/jats:bold>\u2002Our results suggest that there may be an abnormality of phospholipid metabolism in the brain in CFS.<\/jats:p>","DOI":"10.1034\/j.1600-0447.2002.01300.x","type":"journal-article","created":{"date-parts":[[2003,3,10]],"date-time":"2003-03-10T10:09:27Z","timestamp":1047290967000},"page":"224-226","source":"Crossref","is-referenced-by-count":62,"title":["Relative increase in choline in the occipital cortex in chronic fatigue syndrome"],"prefix":"10.1111","volume":"106","author":[{"given":"B. K.","family":"Puri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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