{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T23:10:07Z","timestamp":1697584207689},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,5,26]],"date-time":"2002-05-26T00:00:00Z","timestamp":1022371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p>Parasympathomimetics or cholinesterase inhibitors taken orally may relieve dry\u2010mouth symptoms, but this route of administration is often associated with adverse systemic reactions. In the present study, an animal model was worked out aimed at stimulating the submucosal glands and avoiding systemic effects. In the anesthetized ferret, saliva from the parotid, sublingual and submandibular glands was prevented from reaching the mouth. Vehicle or physostigmine was applied topically for 10\u2003min on the buccal and labial mucosa on one side, while the other side served as a control. Fluid from each side was collected every 5\u2003min Mean basal secretion was 0.17\u2003mg\u20035\u2003min<jats:sup>\u22121<\/jats:sup>. The response to physostigmine 0.1% did not exceed that of the vehicle. At higher concentrations the responses lasted 80\u2013120\u2003min. Peak secretion was nine (0.25% physostigmine), 13 (0.5% physostigmine) and 40 (1% physostigmine) times higher than baseline. At 1% physostigmine, the secretion from the control side was elevated, and a small flow from the duct\u2010cannulated parotid gland occurred, indicating systemic effects. Arterial blood pressure was well maintained. Additional observations on the duct\u2010cannulated zygomatic gland showed that secretion from this gland increased already within the 10\u2010min period of application of physostigmine to the overlying mucosa. The distance between the mucosa and the zygomatic gland was only about 1\u2003mm. Physostigmine\u2010induced secretion was abolished by atropine. Local gland stimulation may be an attractive alternative for the treatment of dry mouth.<\/jats:p>","DOI":"10.1034\/j.1600-0447.2002.201249.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T19:46:55Z","timestamp":1047412015000},"page":"230-236","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Secretion from submucosal salivary glands of the ferret in response to a cholinesterase inhibitor applied onto the oral mucosa"],"prefix":"10.1111","volume":"110","author":[{"given":"J\u00f6rgen","family":"Ekstr\u00f6m","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert F.","family":"Helander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,5,26]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"179","volume-title":"The salivary system.","author":"Sreebny LM","year":"1988"},{"key":"e_1_2_6_3_2","first-page":"283","article-title":"Primary Sj\u00f6gren's syndrome: a subjective description of the disease","volume":"8","author":"Bjerrum K","year":"1990","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199308053290603"},{"key":"e_1_2_6_5_2","first-page":"75","article-title":"Reference guide to drugs and dry mouth","volume":"5","author":"Sreebny LM","year":"1986","journal-title":"Gerontology"},{"key":"e_1_2_6_6_2","first-page":"391","article-title":"Drug\u2010induced xerostomia","volume":"57","author":"Butt GM","year":"1991","journal-title":"J Can Dent Assoc"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.1984.tb00565.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1997.tb00928.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199549010-00010"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(81)90031-X"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01839318"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000061124"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02144740"},{"key":"e_1_2_6_14_2","first-page":"665","volume-title":"Handbook of physiology, alimentary canal","author":"Emmelin N","year":"1967"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1974.sp002236"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1988.sp003129"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1998.sp004154"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000144823"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-1281(78)80058-0"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1963.tb16666.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2001.00129.x"}],"container-title":["European Journal of Oral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0447.2002.201249.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0447.2002.201249.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0447.2002.201249.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T22:40:19Z","timestamp":1697582419000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0447.2002.201249.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5,26]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1034\/j.1600-0447.2002.201249.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0447.2002.201249.x","archive":["Portico"],"relation":{},"ISSN":["0909-8836","1600-0722"],"issn-type":[{"value":"0909-8836","type":"print"},{"value":"1600-0722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5,26]]},"assertion":[{"value":"2002-05-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}