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Gingival crevicular fluid was collected at baseline from one interproximal site at a painful and a non\u2010painful contralateral tooth from 54 adult patients. Sampling was repeated after 1\u2003wk in a subset of 21 subjects. Samples were analysed for SP, NKA, and CGRP using radioimmunoassay. The mean levels of SP and NKA were significantly higher in gingival crevicular fluid from painful teeth compared with non\u2010painful teeth. The level of SP in the GCF of painful teeth fell significantly 1\u2003wk after pulpectomy. In contralateral teeth, there were no significant differences in the levels of SP and NKA after 1\u2003wk. It is concluded that SP and NKA are present in significantly greater amounts in the GCF of painful teeth compared with healthy teeth.<\/jats:p>","DOI":"10.1034\/j.1600-0447.2002.21236.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T19:46:55Z","timestamp":1047412015000},"page":"185-191","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Quantitative analysis of substance P, neurokinin A and calcitonin gene\u2010related peptide in gingival crevicular fluid associated with painful human teeth"],"prefix":"10.1111","volume":"110","author":[{"given":"Lama A.","family":"Awawdeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fionnuala T.","family":"Lundy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard 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