{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:13:48Z","timestamp":1762100028605},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,2,7]],"date-time":"2003-02-07T00:00:00Z","timestamp":1044576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> A mitochondrial disease might be considered when depressive disorder is associated with diabetes mellitus or other symptoms commonly found in mitochondrial disease. Scattered regional cerebral blood flow (rCBF) decreases and increases have been reported in depressive and mitochondrial disorders. A 61\u2010year\u2010old male patient with early adult onset of depressive disorder and a slowly developing multiorgan syndrome including diabetes mellitus was investigated.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> 99mTc\u2010HMPAO rCBF SPECT and muscle biopsy to assess mitochondrial functions were performed in the patient.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Alterations of rCBF were found in the patient, with the most pronounced decreases in the left dorsolateral frontal and inferior parietal lobes, and the most pronounced increases in the bilateral superior parietal lobes. Muscle biopsy revealed myopathy and decrease of mitochondrial adenosine triphosphate production rates (MAPRs).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The MAPRs decreases support the suspicion of mitochondrial dysfunction in the patient. A subgroup of depressed patients may have mitochondrial dysfunctions.<\/jats:p>","DOI":"10.1034\/j.1600-0447.2003.02188.x","type":"journal-article","created":{"date-parts":[[2003,3,10]],"date-time":"2003-03-10T10:10:43Z","timestamp":1047291043000},"page":"233-239","source":"Crossref","is-referenced-by-count":25,"title":["Alterations of rCBF and mitochondrial dysfunction in major depressive disorder: a case report"],"prefix":"10.1111","volume":"107","author":[{"given":"A.","family":"Gardner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pagani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Wibom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Nennesmo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Jacobsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"H\u00e4llstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,2,7]]},"reference":[{"key":"e_1_2_16_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.8.694"},{"key":"e_1_2_16_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199905002-00002"},{"key":"e_1_2_16_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2000.102003178.x"},{"key":"e_1_2_16_5_2","first-page":"51","volume-title":"Brain activation","author":"Roland PE.","year":"1993"},{"key":"e_1_2_16_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200012000-00005"},{"key":"e_1_2_16_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/90.11.657"},{"key":"e_1_2_16_8_2","first-page":"978","article-title":"Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke\u2010like episodes (MELAS) syndrome. An autopsy report","volume":"122","author":"Prayson RA","year":"1998","journal-title":"Arch Pathol Labor Med"},{"key":"e_1_2_16_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.20.2497"},{"key":"e_1_2_16_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115856"},{"key":"e_1_2_16_11_2","first-page":"709","article-title":"Mitochondrial myopathy associated with sudden death in young adults and a novel mutation in the mitochondrial DNA leucine transfer RNA (UUR) gene","volume":"86","author":"Sweeney MG","year":"1993","journal-title":"Quart J Med"},{"key":"e_1_2_16_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00280-1"},{"key":"e_1_2_16_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00005-X"},{"key":"e_1_2_16_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420220"},{"key":"e_1_2_16_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.1.82"},{"key":"e_1_2_16_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.31.1.45"},{"key":"e_1_2_16_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00199-9"},{"key":"e_1_2_16_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00344185"},{"key":"e_1_2_16_19_2","first-page":"961","article-title":"SPECT findings in mitochondrial encephalomyopathy","volume":"39","author":"Watanabe Y","year":"1998","journal-title":"J Nucl Med"},{"key":"e_1_2_16_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050005"},{"key":"e_1_2_16_21_2","unstructured":"GardnerA JohanssonA WibomRet al.Alterations of mitochondrial function and correlations with personality traits in selected major depressive disorder patients.J Affect Disord in press."},{"key":"e_1_2_16_22_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_2_16_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00134-7"},{"key":"e_1_2_16_24_2","unstructured":"GustavssonJP.Stability and validity of self\u2010reported personality traits. Contributions to the evaluation of the Karolinska Scales of Personality [dissertation]. Stockholm:Department of Clinical Neuroscience and the Institute for Environmental Medicine Karolinska Institutet 1997."},{"key":"e_1_2_16_25_2","volume-title":"Psykologhandbok, Del I (Psychological manual, Part I)","author":"Bergman H","year":"1982"},{"key":"e_1_2_16_26_2","doi-asserted-by":"crossref","unstructured":"GardnerA PaganiM JacobssonHet al.Differences in resting state rCBF assessed with 99mTc\u2010HMPAO SPECT and brain atlas matching between depressed patients with and without tinnitus.Nucl Med Commun2002;23:429\u2013439.","DOI":"10.1097\/00006231-200205000-00002"},{"key":"e_1_2_16_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-001-0676-2"},{"key":"e_1_2_16_28_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.7.1.82"},{"key":"e_1_2_16_29_2","doi-asserted-by":"publisher","DOI":"10.1159\/000029163"},{"key":"e_1_2_16_30_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.10.1097"},{"key":"e_1_2_16_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4927(96)02689-3"},{"key":"e_1_2_16_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050950"},{"key":"e_1_2_16_33_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17948"},{"key":"e_1_2_18_2_2","doi-asserted-by":"crossref","unstructured":"GardnerA PaganiM WibomRet al.Alterations of rCBF and mitochondrial dysfunction in major depressive disorder: a case report.Acta Psychiatr Scand2003;107:233\u2013238.","DOI":"10.1034\/j.1600-0447.2003.02188.x"},{"key":"e_1_2_18_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3201231"},{"key":"e_1_2_18_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/331717a0"},{"key":"e_1_2_18_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17948"},{"key":"e_1_2_18_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/90.11.657"},{"key":"e_1_2_18_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400668"},{"key":"e_1_2_18_8_2","first-page":"A403","article-title":"An incidence study of stroke secondary to MELAS in the young","volume":"48","author":"Henderson GV","year":"1997","journal-title":"Neurology"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0447.2003.02188.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0447.2003.02188.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0447.2003.02188.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T22:56:32Z","timestamp":1697410592000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0447.2003.02188.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2,7]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["10.1034\/j.1600-0447.2003.02188.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0447.2003.02188.x","archive":["Portico"],"relation":{},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,2,7]]}}}