{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:06:12Z","timestamp":1791295572955,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":3101,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>In shigellosis, bacterial infection is associated with an extensive inflammation of the rectal mucosa, resulting in bloody dysentery. The role of T\u2010cell\u2010mediated pro\u2010inflammatory mechanisms has been implicated in this process, but the specific role of T\u2010cell subsets is still not well understood. In this study we attempted to identify the changes in T\u2010cell populations in patients with shigellosis during the disease course. The T\u2010cell subset distribution was analyzed by immunohistochemistry in the rectal mucosa and by immuno\u2010flow cytometry in the peripheral blood. Blood and rectal biopsies were studied from patients with <jats:italic>Shigella dysenteriae<\/jats:italic> 1 (n=11) and <jats:italic>S. flexneri<\/jats:italic> (n=11) infection and 20 healthy age\u2010matched controls. We found an expansion of \u03b3,\u03b4<jats:sup>+<\/jats:sup>T cells in the rectal mucosa, but a decrease in the percentage of \u03b3,\u03b4<jats:sup>+<\/jats:sup>T cells in the blood in acute shigellosis. There was also a preferential increase in CD8<jats:sup>+<\/jats:sup> T cells in the surface epithelium of rectal tissue in patients infected with <jats:italic>S. dysenteriae<\/jats:italic> 1, but not in patients infected with <jats:italic>S. flexneri<\/jats:italic>. Our findings suggest that the rectal mucosal inflammation in shigellosis is associated with an expansion of T cells, in particular CD8<jats:sup>+<\/jats:sup> and \u03b3,\u03b4<jats:sup>+<\/jats:sup>T\u2010cell subsets in the gut mucosa, which may be of importance for the pathogenesis of shigellosis.<\/jats:p>","DOI":"10.1034\/j.1600-0463.2000.d01-52.x","type":"journal-article","created":{"date-parts":[[2003,10,15]],"date-time":"2003-10-15T02:34:58Z","timestamp":1066185298000},"page":"251-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Disease\u2010dependent changes in T\u2010cell populations in patients with shigellosis"],"prefix":"10.1111","volume":"108","author":[{"given":"Dilara","family":"Islam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birger","family":"Christensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0167-5699(97)80010-2","article-title":"Sentinel function of broadly reactive human \u03b3\u03b4T cells","volume":"18","author":"Gennaro DL.","year":"1997","journal-title":"Immunol Today"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830210429"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1991.tb00590.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830241219"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.4049\/jimmunol.147.10.3360","article-title":"A predominance of the T cell receptor V\u03b32\/V\u03b42 subset in human mycobacteria\u2010responsive T cells suggests germline gene encoded recognition","volume":"147","author":"Panchamoorthy G.","year":"1991","journal-title":"J Immunol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115837"},{"key":"e_1_2_1_8_2","first-page":"281","article-title":"Function and specificity of human gamma\/delta\u2010positive T cells","volume":"11","author":"Kabelitz D.","year":"1992","journal-title":"Crit Rev Immunol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.6.1331"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1128\/iai.60.6.2554-2558.1992","article-title":"Predominant expansion of V\u03b39\/V\u03b42 T cells in a tularemia patient","volume":"60","author":"Sumida T.","year":"1992","journal-title":"Infect Immun"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1990.tb03200.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.4049\/jimmunol.151.4.1765","article-title":"Regional specialization of the mucosal immune system. 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