{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:49:17Z","timestamp":1761580157670},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":3101,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>In this study we examined the in vitro vacuolating cytotoxic activity of <jats:italic>Helicobacter pylori<\/jats:italic>, which is a gram\u2010negative microaerophilic curved bacterium and a causative agent of gastritis, peptic ulcer and gastric ulcer. A vacuolating cytotoxin assay was performed to assess the vacuolating activity of 40 strains (20 gastritis, 11 gastric ulcer, and 9 duodenal ulcer), which were obtained from patients undergoing upper gastrointestinal endoscopy. The Vero cell line was used in the cytotoxic assay. Of the 40 isolates, 24 (12 gastritis, 6 gastric ulcer, 6 duodenal ulcer) were cytotoxic for the Vero cell line at 1:4 and 1:8 dilutions. Thus, vacuolating cytotoxin of <jats:italic>H. pylori<\/jats:italic> affects the Vero cell line, but it seems there is no correlation between the positivity of the strains and the risk of any particular <jats:italic>H. pylori<\/jats:italic> disease.<\/jats:p>","DOI":"10.1034\/j.1600-0463.2000.d01-59.x","type":"journal-article","created":{"date-parts":[[2003,10,15]],"date-time":"2003-10-15T02:34:58Z","timestamp":1066185298000},"page":"293-295","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vacuolating cytotoxic activity of 40 <i>Helicobacter pylori<\/i> strains isolated from Turkish 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