{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:25:45Z","timestamp":1775042745126,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,10,2]],"date-time":"2003-10-02T00:00:00Z","timestamp":1065052800000},"content-version":"vor","delay-in-days":853,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:p>Subacute granulomatous thyroiditis (SAT) is a self\u2010limiting systemic inflammatory disorder with possible transient expression of thyroid antibodies. Persistent hypothyroidism is uncommon. The interleukin\u20101 receptor antagonist IL\u20101ra is an inhibitor of IL\u20101 activity and allele 2 of the IL\u20101ra gene is associated with inflammatory diseases and IL\u20101ra production. Forty\u2010eight subjects with SAT were investigated. Polymorphisms of IL\u20101ra, IL\u20101\u03b2\u2010511 and TNF\u03b1 genes were studied with respect to thyroid peroxidase antibodies (TPOab), thyroglobulin antibodies, C\u2010reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Serum IL\u20101ra levels were measured. An increased allelic frequency (43% vs 22%, p=0.039) and carriage rate (79% vs 41%, p=0.018) for IL\u20101ra allele 2 were observed with expression of TPOab in 14 (29.2%) subjects compared with those with negative findings. The carriage rate for both IL\u20101ra allele 2 and IL\u20101\u03b2\u2010511 allele 2 was also increased with TPOab expression (71% vs 27%, p=0.004, respectively). No difference in allele frequency or carriage rate was found compared with healthy controls. Serum IL\u20101ra levels correlated with S\u2010CRP (r=0.41, p=0.004) and ESR (r=0.34, p=0.016), but the association with genes or thyroid antibodies was statistically insignificant. S\u2010CRP levels and ESR were lower and negatively correlated with expression of TPOab (r=\u22120.27, p=0.046 and r=\u22120.32, p=0.017). This study describes the multiplicity of the mechanisms responsible for the severity of the acute\u2010phase response during the course of SAT. IL\u20101ra may have a significant anti\u2010inflammatory role in SAT. Presence of IL\u20101ra allele 2 increases the risk of developing TPOab.<\/jats:p>","DOI":"10.1034\/j.1600-0463.2001.090608.x","type":"journal-article","created":{"date-parts":[[2003,10,15]],"date-time":"2003-10-15T02:36:38Z","timestamp":1066185398000},"page":"454-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Allele 2 of interleukin\u20101 receptor antagonist gene increases the risk of thyroid peroxidase antibodies in subacute thyroiditis"],"prefix":"10.1111","volume":"109","author":[{"given":"K.","family":"Luotola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Mantula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Salmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.\u2010M.","family":"Haapala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Laippala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hurme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,10,2]]},"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0463.2001.090608.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0463.2001.090608.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T18:35:06Z","timestamp":1700418906000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0463.2001.090608.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1034\/j.1600-0463.2001.090608.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0463.2001.090608.x","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6]]},"assertion":[{"value":"2003-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}