{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:45:03Z","timestamp":1761518703694},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,6,20]],"date-time":"2002-06-20T00:00:00Z","timestamp":1024531200000},"content-version":"vor","delay-in-days":139,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p>This paper reports macro\u2010 and microscopic changes in hyperfunctioning thyroid nodules (HTN), initially diagnosed as solitary, in patients treated with percutaneous ethanol injection (PEI). In 78 patients, benign solitary HTN were diagnosed by clinical and hormonal examination. High resolution ultrasonography confirmed the solitary nodule. The results of fine needle aspiration biopsy (FNAB), performed twice, ruled out malignancy of the nodule. The patients were referred for PEI treatment. At 1\u2010year follow\u2010up, newly formed thyroid nodules, whose volumes increased, were detected in five patients (6.4%) with HTN, initially diagnosed as solitary. Therefore, these patients were operated on. Subtotal thyroidectomy was performed. At the intraoperative macroscopic evaluation, a hard fibrous solid mass was found in place of three nodules (n<jats:sub>1<\/jats:sub>, n<jats:sub>2<\/jats:sub>, n<jats:sub>3<\/jats:sub>) following PEI treatment. The middle area of the cut surface of PEI\u2010treated nodules (n<jats:sub>4<\/jats:sub> and n<jats:sub>5<\/jats:sub>) in the other two patients was firm and haemorrhagic, surrounded by a fibrous mass. Histolopathologic examination of n<jats:sub>1<\/jats:sub>, n<jats:sub>2<\/jats:sub> and n<jats:sub>3<\/jats:sub> revealed fibrosis and hyalinosis. Examination of n<jats:sub>4<\/jats:sub> and n<jats:sub>5<\/jats:sub> showed haemorrhagic necrosis in the middle of the nodules surrounded by fibrous tissue.<\/jats:p>","DOI":"10.1034\/j.1600-0463.2002.100208.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T03:25:31Z","timestamp":1047353131000},"page":"172-176","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Histologic changes in thyroid nodules after percutaneous ethanol injection in patients subsequently operated on due to new focal thyroid lesions"],"prefix":"10.1111","volume":"110","author":[{"given":"Lech","family":"Pomorski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Bartos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,6,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302253280807"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1360240"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805143382007"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1320661"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198707093170202"},{"key":"e_1_2_5_7_2","first-page":"103","article-title":"Incidence of hypothyroidism occurring long after iodine\u2010131 therapy for hyperthyroidism","volume":"23","author":"Holm LE","year":"1982","journal-title":"J Nucl Med"},{"key":"e_1_2_5_8_2","first-page":"1638","article-title":"Optimalization or radioiodine therapy of thyrotoxicosis: what have we learned after 50 years","volume":"34","author":"Shapiro B","year":"1993","journal-title":"J Nucl Med"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1350383"},{"key":"e_1_2_5_10_2","first-page":"143","article-title":"Percutaneous ethanol injection in treatment of benign nonfunctional and hyperfunctional thyroid nodules","volume":"95","author":"Komorowski J","year":"1998","journal-title":"Cytobios"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/cryo.1999.2209"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/cryo.2000.2264"},{"key":"e_1_2_5_13_2","first-page":"157","article-title":"The influence of hyperthermia on the thyroid gland in the rat","volume":"2","author":"Amsolik M","year":"1999","journal-title":"Onkol Pol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.295.6597.529"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.175.3.2188302"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03165389"},{"key":"e_1_2_5_17_2","first-page":"827","article-title":"Echo\u2010guided percutaneous alcohol injections of cold non\u2010neoplastic thyroid nodules","volume":"85","author":"Goletti O","year":"1993","journal-title":"Preliminary experience Radiol Med"},{"key":"e_1_2_5_18_2","first-page":"699","article-title":"Is percutaneous ethanol injection a useful alternative for the treatment of the cold benign thyroid nodule?","volume":"7","author":"Caraccio N","year":"1997","journal-title":"Five years' experience. 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