{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T16:25:35Z","timestamp":1725726335785},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":479,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:p>There is increasing evidence of an interaction between the nervous and the immune systems. The aim of this study was to investigate the r\u00f4le of calcitonin gene\u2010related peptide (CGRP) in the modulation of the elicitation of immediate and delayed, immunological and non\u2010immunological reactions in human skin. CGRP (13 pmol and 39 pmol), and the CGRP\u2010antagonist, CGRP<jats:sub>\/8\u201337\/<\/jats:sub>, (50 pmol and 500 pmol) were injected intracutaneously prior to provocation tests. Patients with allergy to nickel were provoked with nickel sulfate epicutaneously, and the reactions were evaluated by a clinical scoring system (guidelines of the International Contact Dermatitis Research Group). Patients with allergy to birch pollen were provoked by a prick test with the allergen, and the volume of the weals was measured. The patients were also provoked with tuberculin (delayed immunologic reaction), benzalkonium chloride (irritant contact dermatitis), UV\u2010light and benzoic acid (non\u2010immunologic contact urticaria). The test reactions were estimated by planimetry. CGRP<jats:sub>\/8\u201337\/<\/jats:sub> exerted dual effects on allergic contact dermatitis, causing potentiation at a dose of 500 pmol (<jats:italic>p<\/jats:italic>=0.004) and inhibition at a dose of 50 pmol (<jats:italic>p<\/jats:italic>=0.012). Other reactions were not significantly affected by the pretreatments. The results suggest that CGRP participates in delayed inflammatory reactions, but is not involved in immediate immunologic reactions.<\/jats:p>","DOI":"10.1034\/j.1600-0536.2000.043003137.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T12:57:29Z","timestamp":1047387449000},"page":"137-143","source":"Crossref","is-referenced-by-count":10,"title":["Dual effects of CGRP\u2010antagonist on allergic contact dermatitis in human skin"],"prefix":"10.1034","volume":"43","author":[{"given":"Joanna","family":"Wallengren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0536.2000.043003137.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0536.2000.043003137.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T01:35:38Z","timestamp":1700703338000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0536.2000.043003137.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["10.1034\/j.1600-0536.2000.043003137.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0536.2000.043003137.x","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}