{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T01:57:47Z","timestamp":1794275867137,"version":"4.9.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,1,10]],"date-time":"2003-01-10T00:00:00Z","timestamp":1042156800000},"content-version":"vor","delay-in-days":343,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Beckwith\u2013Wiedeman syndrome (BWS) is a rare genetic disorder, linked to an alteration on the short arm of chromosome 11 that comprises multiple congenital anomalies. Macroglossia is the predominant finding, with subsequent protrusion of dentoalveolar structures, which results in a protruding mandible, anterior open bite, abnormally obtuse gonial angle and increased mandibular length. A less\u2010invasive treatment with orthopaedic appliances in a patient with early tongue reduction is presented. This work summarizes the oral signs linked to macroglossia, and highlights the influence of macroglossia on mandibular growth structures. In our opinion, glossotomy could be carried out in the paediatric patient as a preventive measure in that it curbs the tongue's influence on skeletal growth and dramatically reduces the duration and extensiveness of subsequent treatment.<\/jats:p>","DOI":"10.1034\/j.1600-0544.2002.01165.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T15:45:05Z","timestamp":1047483905000},"page":"59-63","source":"Crossref","is-referenced-by-count":17,"title":["A less\u2010invasive approach with orthodontic treatment in Beckwith\u2013Wiedeman patients"],"prefix":"10.1111","volume":"5","author":[{"given":"A","family":"Giancotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Romanini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Di","family":"Girolamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Arcuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,1,10]]},"reference":[{"key":"e_1_2_7_2_2","unstructured":"BeckwithJB.Extreme Cytomegaly of the Adrenal Fetal Cortex Omphalocele Hyperplasia of Kidneys and Pancreas and Leydig\u2010 Cell Hyperplasia \u2013 Another Syndrome?Presented at the Annual Meeting of Western Society for Pediatric Research November 11 1963. Los Angeles CA 1963."},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992289503400605"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00496807"},{"key":"e_1_2_7_5_2","first-page":"74","article-title":"Sindrome di Beckwith\u2013Wiedeman: un raro caso","volume":"1","author":"Malagola C","year":"1990","journal-title":"Dental Cadmos"},{"key":"e_1_2_7_6_2","first-page":"104","article-title":"Sindrome di Beckwith\u2013Wiedeman: presentazione di un caso clinico","volume":"16","author":"Preda GE","year":"1989","journal-title":"Dental Cadmos"},{"key":"e_1_2_7_7_2","first-page":"326","article-title":"Long term changes in dentoskeletal pattern in a case with Beckwith\u2013Wiedeman Syndrome following tongue reduction and orthodontic treatment","volume":"70","author":"Shouichi M","year":"2000","journal-title":"Angle Orthod"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1994.tb04219.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198502000-00004"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441965"},{"key":"e_1_2_7_11_2","first-page":"564","article-title":"Orthodontic findings of a case of Beckwith\u2013Wiedeman syndrome","volume":"43","author":"Kamogashira K","year":"1984","journal-title":"J Jpn Orthod Soc"},{"key":"e_1_2_7_12_2","first-page":"179","article-title":"The Beckwith\u2013Wiedeman syndrome: a longitudinal study of the macroglossia and dentofacial complex","volume":"1","author":"Friede H","year":"1985","journal-title":"J Craniofac Genet Dev Biol Suppl"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(85)80083-5"},{"key":"e_1_2_7_14_2","first-page":"212","article-title":"Surgical correction of macroglossia in Beckwith\u2013Wiedeman syndrome","volume":"36","author":"Sokoloski PM","year":"1978","journal-title":"J Oral Surg"},{"key":"e_1_2_7_15_2","first-page":"316","volume":"119","author":"Thornurn MJ","year":"1970","journal-title":"Am J Dis Child"},{"key":"e_1_2_7_16_2","first-page":"915","article-title":"A radiation hybrid map of the distal short arm of human chromosome 11, containing the Beckwith\u2013Wiedeman and associate embryonal tumor disease loci","volume":"52","author":"Richard CW, III","year":"1993","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320420441"},{"key":"e_1_2_7_18_2","unstructured":"RuffinoS FrigerioM.GalvagnoG Bosco G. Il problema della macroglossia nel lattante affetto da BWS: descrizione di un caso.Minerva Stomatologica1985:34."},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70115-X"},{"key":"e_1_2_7_20_2","unstructured":"FarkasJG.Anthropometry of the head and face. (ed) 1994 \u2013 2nd ed. New York Raven p. 224\u2013333."},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000214)90:4<283::AID-AJMG4>3.0.CO;2-F"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992286800700613"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-198502000-00008"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199507000-00004"}],"container-title":["Orthodontics &amp; Craniofacial Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0544.2002.01165.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0544.2002.01165.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0544.2002.01165.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T12:04:46Z","timestamp":1746878686000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0544.2002.01165.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["10.1034\/j.1600-0544.2002.01165.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0544.2002.01165.x","archive":["Portico"],"relation":{},"ISSN":["1601-6335","1601-6343"],"issn-type":[{"value":"1601-6335","type":"print"},{"value":"1601-6343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2]]}}}