{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:52:23Z","timestamp":1780491143802,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2003,8,11]],"date-time":"2003-08-11T00:00:00Z","timestamp":1060560000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Structured Abstract<\/jats:title><jats:p> <jats:bold>\n            <jats:italic>Author \u2013<\/jats:italic>\n          <\/jats:bold> Radlanski RJ<\/jats:p><jats:p><jats:bold>Objectives \u2013<\/jats:bold> Basic research concerning craniofacial development presently runs along two pathways, namely the molecular and the morphometric. This gap needs to be bridged.<\/jats:p><jats:p><jats:bold>Design \u2013<\/jats:bold> Using histological serial sections of human fetuses computer\u2010aided three\u2010dimensional reconstructions were made (Software Analysis, SIS) with special focus given to all anatomical structures of the orofacial region of the growing head.<\/jats:p><jats:p><jats:bold>Results \u2013<\/jats:bold> All reconstructions can be viewed from any rotation and they are available for virtual dissection according to anatomical rules. As an example, the prenatal development of the human mandible with the formation of the mental foramen therein is described. Furthermore, the spatial arrangement of bone, cartilage and nerves is presented in three dimensions in different developmental stages. The interaction of tissues with possible morphogenetic interaction is discussed.<\/jats:p><jats:p><jats:bold>Conclusions \u2013<\/jats:bold> This work serves as a reference system for prenatal development in comparison with pathological development.<\/jats:p>","DOI":"10.1034\/j.1600-0544.2003.240.x","type":"journal-article","created":{"date-parts":[[2004,11,15]],"date-time":"2004-11-15T13:19:39Z","timestamp":1100524779000},"page":"89-94","source":"Crossref","is-referenced-by-count":12,"title":["Prenatal craniofacial morphogenesis: four\u2010dimensional visualization of morphogenetic processes"],"prefix":"10.1111","volume":"6","author":[{"given":"RJ","family":"Radlanski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,8,11]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.14.2977"},{"key":"e_1_2_9_3_2","first-page":"249","article-title":"Morphogenesis of human tooth primordia: the importance of 3D computer\u2010assisted reconstruction","volume":"39","author":"Radlanski RJ.","year":"1995","journal-title":"Int J Dev Biol"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02952679"},{"key":"e_1_2_9_5_2","volume-title":"The Stages of Human Development Before Birth. 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