{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:12:50Z","timestamp":1779261170695,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,1,12]],"date-time":"2002-01-12T00:00:00Z","timestamp":1010793600000},"content-version":"vor","delay-in-days":195,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Lipodermatosclerosis refers to a sclerosing panniculitis and dermopathy of the lower extremities sometimes seen in association with venous ulceration. Matrix metalloproteinases are implicated in the pathogenesis of venous leg ulcers and the <jats:italic>in vitro<\/jats:italic> activation of recombinant MMP\u20102 is controlled by the plasminogen activation system. To better understand the role of plasminogen activation in the pathogenesis of venous leg ulcers we investigated fibrinolytic factors and their inhibitors in tissue samples of lipodermatolsclerosis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The expression and the functional state of the urokinase\u2010type plasminogen activator (uPA), the tissue\u2010type plasminogen activator (tPA), the urokinase receptor (CD87), the plasminogen activator inhibitors\u20101 and \u20102 (PAI\u20101 and PAI\u20102) were assayed using reverse transcription polymerase chain reaction, Western blot, fibrin zymography and immunohistochemistry analyses in tissue samples of lipodermatosclerosis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Our results provide direct evidence of elevated expression of uPA (p&lt;0.01) and CD87 (p&lt;0.01) mRNA and protein level in lipodermatosclerosis in comparison with healthy skin. By immunohistochemistry, elevated expression of uPA and CD87 could be detected. Fibrin zymography showed significantly elevated endogenous uPA activity (p&lt;0.01) in liposclerotic lesions compared to healthy controls.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our findings indicate that elevated plasminogen activation in lipodermatosclerotic tissue may play a crucial role in the pathogenesis of venous leg ulceration.<\/jats:p>","DOI":"10.1034\/j.1600-0560.2001.028006291.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T13:53:57Z","timestamp":1047390837000},"page":"291-297","source":"Crossref","is-referenced-by-count":16,"title":["The role of the urokinase\u2010type plasminogen activator (uPA) and its receptor (CD87) in lipodermatosclerosis"],"prefix":"10.1111","volume":"28","author":[{"given":"Yared","family":"Herouy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Aizpurua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Stetter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Dichmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Idzko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Gitsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Vanscheidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin","family":"Sch\u00f6pf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Norgauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70085-8"},{"key":"e_1_2_6_3_2","first-page":"1085","article-title":"Sequential changes in histologic pattern and extracellular matrix deposition during the healing of chronic venous ulcers.","volume":"141","author":"Herrick SE","year":"1992","journal-title":"Am J Pathol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00369.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.11.5872"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.9.2319"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12534677"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(97)80126-3"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.6.1029"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.12.5899"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"7262","DOI":"10.1016\/S0021-9258(18)34566-6","article-title":"A proenzyme form of human urokinase.","volume":"257","author":"Wun TC","year":"1982","journal-title":"J Biol Chem"},{"key":"e_1_2_6_12_2","first-page":"3066","article-title":"Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro.","volume":"54","author":"Stahl A","year":"1994","journal-title":"Canc Res"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1002762"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1182\/blood.V86.11.4007.bloodjournal86114007","article-title":"Biological and clinical aspects of plasminogen activator inhibitor type\u20102.","volume":"86","author":"Kruithof EKO","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_15_2","first-page":"3656","article-title":"Expression and localization of urokinase\u2010type plasminogen activator in human astrocytomas in vivo.","volume":"54","author":"Yamamoto M","year":"1994","journal-title":"Canc Res"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02333-3"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800660314"},{"key":"e_1_2_6_18_2","unstructured":"JarretPE BurnandKG MorlandM BrowseNL. 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