{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:53:11Z","timestamp":1782913991435,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,4,23]],"date-time":"2002-04-23T00:00:00Z","timestamp":1019520000000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Cutaneous manifestations of B\u2010cell chronic lymphocytic leukemia (B\u2010CLL) comprise a wide spectrum of clinicopathologic presentations. In some cases, onset of skin lesions is triggered by antigenic stimulation, and specific skin infiltrates at sites of previous herpes simplex or herpes zoster infection have been well documented. Specific skin manifestations of B\u2010CLL can also be observed at sites typical for lymphadenosis benigna cutis (nipple, scrotum, earlobe), a <jats:italic>Borrelia burgdorferi<\/jats:italic>\u2010associated cutaneous B\u2010cell pseudolymphoma.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We studied specific skin manifestations of B\u2010CLL arising at sites typical for <jats:italic>B. burgdorferi<\/jats:italic>\u2010induced lymphadenosis benigna cutis, analyzing tissues for presence of <jats:italic>B. burgdorferi<\/jats:italic> DNA using the polymerase chain reaction (PCR) technique. Six patients with B\u2010CLL (M\u2003:\u2003F =\u200a4\u2003:\u20032; mean age: 67.8) presented with specific skin lesions located on the nipple (four cases) and scrotum (two cases).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Clinically there were solitary erythematous plaques or nodules. Histology revealed in all cases a dense, monomorphous infiltrate of small lymphocytes showing an aberrant CD20<jats:sup>+<\/jats:sup>\/CD43<jats:sup>+<\/jats:sup> phenotype. In all cases monoclonality was demonstrated by PCR analysis of the J<jats:sub>H<\/jats:sub> gene rearrangement. PCR analysis showed in four of the six cases the presence of DNA sequences specific for <jats:italic>B.burgdorferi<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Our study demonstrates that infection with <jats:italic>B. burgdorferi<\/jats:italic> can trigger the development of specific cutaneous infiltrates in patients with B\u2010CLL.<\/jats:p>","DOI":"10.1034\/j.1600-0560.2002.290303.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T13:54:58Z","timestamp":1047390898000},"page":"142-147","source":"Crossref","is-referenced-by-count":58,"title":["Specific cutaneous infiltrates of B\u2010cell chronic lymphocytic leukemia (B\u2010CLL) at sites typical for <i>Borrelia burgdorferi<\/i> infection"],"prefix":"10.1111","volume":"29","author":[{"given":"Lorenzo","family":"Cerroni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"H\u00f6fler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"B\u00e4ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerlinde","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Kerl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,4,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199608000-00009"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(84)70145-9"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950701)76:1<26::AID-CNCR2820760105>3.0.CO;2-J"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1991.tb00155.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1993.tb00658.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/jn\/122.2.294","article-title":"Atherogenic diets enhance endotoxin\u2010stimulated interleukin\u20101 and tumor necrosis factor gene expression in rabbit aorta","volume":"122","author":"Fleet JC","year":"1992","journal-title":"J Nutr"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.3.524-532.1991"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.43.11.888"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1984.tb00899.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1993.tb00662.x"},{"key":"e_1_2_5_12_2","first-page":"5","article-title":"Les manifestations cutanees des leucemies lymphoides chroniques (LLC). 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