{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:12:14Z","timestamp":1761707534999},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T00:00:00Z","timestamp":1027555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The delineation of radial and vertical growth phases in primary cutaneous malignant melanomas has contributed to our understanding of melanoma progression and has enhanced the ability of pathologists to provide clinicians with meaningful prognostic information. Vertical growth phase (VGP) lesions have the potential to metastasize, but radial growth phase (RGP) melanomas are believed to lack competence for metastasis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We have identified three cases in which metastasis occurred in association with lesions initially interpreted as RGP melanomas. To determine whether these cases truly represented exceptional metastasizing RGP melanomas or VGP lesions incorrectly identified as RGP lesions, careful microscopic re\u2010review of these cases was performed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In one case, additional microscopic sectioning revealed a focus of vertical growth that was not evident on the original sections. In the other two cases, only radial growth was found. In one of these cases there was melanoma <jats:italic>in situ<\/jats:italic> with regressive changes, but no evidence for invasive melanoma. In the other, a RGP lesion was associated with an adjacent compound nevus with periadnexal involvement.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> These cases suggest that, while true RGP melanomas have an excellent prognosis, caution must be exercised in defining a lesion as having no metastatic potential when multiple sections of the primary lesion are unavailable, when the lesion is accompanied by regressive changes, or when there is an associated melanocytic nevus. It is possible that strictly defined RGP melanomas may metastasize in very rare cases. Our observations also suggest that metastatic potential is a function of numerous factors, and may not be evaluable on morphological grounds alone.<\/jats:p>","DOI":"10.1034\/j.1600-0560.2002.290704.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T13:55:32Z","timestamp":1047390932000},"page":"407-414","source":"Crossref","is-referenced-by-count":24,"title":["Problems in the interpretation of apparent \u2018radial growth phase\u2019 malignant melanomas that metastasize"],"prefix":"10.1111","volume":"29","author":[{"given":"Liana","family":"Abramova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Craig","family":"L. 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