{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T10:53:11Z","timestamp":1776855191079,"version":"3.51.2"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T00:00:00Z","timestamp":1031097600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p>CD8<jats:sup>+<\/jats:sup> T\u2010cell lymphomas presenting in the skin are rare. We describe the clinical and histological features of 18 patients with CD8<jats:sup>+<\/jats:sup> cutaneous T\u2010cell tumors, which have been divided into four groups. Seven patients had precedent long histories of rashes, which progressively spread in a presentation similar to that of CD4<jats:sup>+<\/jats:sup> mycosis fungoides (MF). Three patients had long\u2010standing localized plaques consistent with a pagetoid reticulosis (PR) pattern. Two patients presented with erythroderma and had peripheral blood involvement consistent with a Sezary syndrome (SS) pattern and had rapidly progressive clinical courses. Six patients presented with cutaneous nodules of varying sizes and had variable outcomes, with two having rapidly progressive disease, two with indolent recurrences and a further two with complete responses to treatment. Histologically, 12 of the 18 cases showed an epidermotropic tumor infiltrate that was most marked in the three PR cases. Prominent periadnexal infiltration was seen in 11 cases. Similar to CD4<jats:sup>+<\/jats:sup> MF, the skin\u2010homing antigen, (cutaneous lymphocyte antigen: CLA), was strongly expressed in 13 of 16 tested cases. Expression of the cytotoxic granule protein granzyme B was noted in a majority of tumor cells in only three of 16 tested cases. We conclude that approximately half of CD8<jats:sup>+<\/jats:sup> cutaneous T\u2010cell lymphomas clinically and histologically resemble CD4<jats:sup>+<\/jats:sup> MF\/SS, whereas presentation as discrete nodular lesions are more common in CD8<jats:sup>+<\/jats:sup> tumors as compared to those that express CD4.<\/jats:p>","DOI":"10.1034\/j.1600-0560.2002.290804.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T13:55:46Z","timestamp":1047390946000},"page":"465-472","source":"Crossref","is-referenced-by-count":70,"title":["Clinical and pathological spectrum of CD8\u2010positive cutaneous T\u2010cell lymphomas"],"prefix":"10.1111","volume":"29","author":[{"given":"Di","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaushali A.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine","family":"Duvic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,9,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.12.3835"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.7.881"},{"key":"e_1_2_6_4_2","first-page":"182A","article-title":"T\u2013PLL and Sezary syndrome have overlapping clinical and pathological features","volume":"14","author":"Washington L","year":"2001","journal-title":"Mod Pathol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200202000-00009"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.8.1024"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03888.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155500750012234"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65144-9"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70074-R"},{"key":"e_1_2_6_11_2","first-page":"725","article-title":"Report of the committee on staging and classification of cutaneous T\u2010cell lymphomas","volume":"63","author":"Bunn PA","year":"1979","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1309\/5WFQ-N12E-DT05-UX1T"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199603)178:3<303::AID-PATH475>3.0.CO;2-I"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880088"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1984.tb07317.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.2.199"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.6.1461"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1309\/3N7P-J84L-JQ9K-G89R"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/archderm.1990.01670300101017","article-title":"CD8+ cutaneous T\u2010cell lymphoma with pagetoid epidermotropism and angiocentric and angiodestructive infiltration","volume":"126","author":"Fujiwara Y","year":"1990","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(93)90426-5"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199012000-00012"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1992.tb03979.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70201-4"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70007-1"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1987.tb01332.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4049\/jimmunol.163.1.466","article-title":"Skin homing (cutaneous lymphocyte\u2010associated antigen\u2010positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis","volume":"163","author":"Akdis M","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1994.tb00250.x"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90067-5"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65372-2"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12337633"},{"key":"e_1_2_6_31_2","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1182\/blood.V92.4.1150","article-title":"Transformation of mycosis fungoides\/Sezary syndrome. clinical characteristics and prognosis","volume":"92","author":"Diamandidou E","year":"1998","journal-title":"Blood"},{"key":"e_1_2_6_32_2","first-page":"69a","article-title":"The histological findings of mycosis fungoides following treatment of large cell transformation","volume":"13","author":"Vakar\u2010Lopez F","year":"2000","journal-title":"Modern Pathol"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0560.2002.290804.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0560.2002.290804.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0560.2002.290804.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T16:32:34Z","timestamp":1697560354000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0560.2002.290804.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1034\/j.1600-0560.2002.290804.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0560.2002.290804.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}