{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:41:25Z","timestamp":1789882885112,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T00:00:00Z","timestamp":1031097600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> There have been several reports of HIV\u2010negative patients with chronic idiopathic CD4+ T lymphocytopenia, the diagnostic criteria for which are: depressed numbers of circulating T lymphocytes (less than 300\/\u00b5l or less than 20%) on more than one occasion; no laboratory evidence of HIV\u20101 or HIV\u20102 infection; and the absence of any defined immunodeficiency or therapy associated with depressed levels of CD4+\u2003T lymphocytes.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We report a patient with disseminated human papillomavirus infection associated with idiopathic CD4+\u2003T\u2010cell lymphocytopenia. A 50\u2010year\u2010old woman presented to the dermatology clinic with a 10\u2010year history of widespread verrucae involving the skin and the cervix.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Biopsy from the arm revealed a common wart. PCR analysis performed from the paraffin\u2010embedded block was strongly positive for HPV type 2. Other HPV types (including EV\u2010associated HPV 5, 8, 14, 15, 17) were not found. Further laboratory work up revealed T\u2010cell lymphocytopenia, with an absolute CD4 count of 21. HIV tests were repeatedly negative. She was treated with interferon A 8 million units SQ three times per week with partial improvement. The patient underwent a hysterectomy for cervical dysplasia and a vulvectomy for vulvar intraepithelial neoplasia. She developed small\u2010cell lung carcinoma and died.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The diagnosis of idiopathic CD4+\u2003T\u2010cell lymphocytopenia should be considered in any patient with widespread viral, fungal, or mycobacterial infection whose HIV test is negative, and appropriate evaluation of the absolute CD4+ counts should be performed.<\/jats:p>","DOI":"10.1034\/j.1600-0560.2002.290809.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T13:55:46Z","timestamp":1047390946000},"page":"502-505","source":"Crossref","is-referenced-by-count":23,"title":["CD4+\u2003T lymphocytopenia with disseminated HPV"],"prefix":"10.1111","volume":"29","author":[{"given":"Cloyce L.","family":"Stetson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald P.","family":"Rapini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen 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