{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:34:28Z","timestamp":1761057268167},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":633,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>Abstract: Approximately one third of thalassaemia patients onrecord in Lebanon have thalassaemia intermedia. We haveanalysed three factors in a panel of 73 patients with this less severeform of the disease in our population: mild \u03b2\u2010globin gene mutations, deletions in the \u03b1\u2010globin gene and the presence of a polymorphismfor the enzyme <jats:italic>Xmn<\/jats:italic>I in the <jats:sup>G<\/jats:sup>\u03b3\u2010promoter region. The results show that the most important contributing factor is the \u03b2\u2010genotype:68% of patients have a mild \u03b2+ mutation (IVSI\u20106, cd29,\u221288 or \u221287), while 26% of patients are positive for the <jats:italic>Xmn<\/jats:italic>I polymorphism associated with increased production ofHbF, which showed strong linkage to particular mutations(IVSII\u20101, cd8 and cd30). However, the genotype\u2013phenotypecorrelation is difficult, because many patients were initially misdiagnosed as thalassaemia major and were started early on regular blood transfusions, which was stopped later on. This illustrates well the importance of an early accurate diagnosis of thalassaemia intermedia for appropriate clinical management.<\/jats:p>","DOI":"10.1034\/j.1600-0609.2000.90087.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T18:48:37Z","timestamp":1047408517000},"page":"237-244","source":"Crossref","is-referenced-by-count":21,"title":["\u03b2\u2010Thalassaemia intermedia in Lebanon"],"prefix":"10.1111","volume":"64","author":[{"given":"M.","family":"Qatanani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Taher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Koussa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Naaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rugless","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Old","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Zahed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0609.2000.90087.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0609.2000.90087.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T07:50:40Z","timestamp":1698565840000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0609.2000.90087.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["10.1034\/j.1600-0609.2000.90087.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0609.2000.90087.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,4]]}}}