{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T09:46:02Z","timestamp":1717062362208},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,9,13]],"date-time":"2002-09-13T00:00:00Z","timestamp":1031875200000},"content-version":"vor","delay-in-days":104,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Constitutive expression of the IL\u20102 receptor (IL\u20102R) on adult T\u2010cell leukemia (ATL) cells and the presence of permanent IL\u20102\u2010dependent ATL cell lines indicate that the signal transduction system via IL\u20102R is a key element for the development of this disease. IL\u20102R is a member of the common \u03b3\u2010chain (\u03b3c)\u2010receptor family and shares \u03b3 with IL\u20104R, IL\u20107R, IL\u20109R, and IL\u201015R. In addition to IL\u20102R, ATL cells express IL\u201015R and respond to IL\u201015. In the present study, we examined other members of this receptor family. ATL cells showed various levels of IL\u20104R\u03b1 (CD124) and IL\u20107R\u03b1 (CD127) expression, and responded to these cytokines. In contrast, ATL cells hardly responded to IL\u20109. As primary samples were a mixed population and the results may have been modified by contaminating normal cells, we used ATL cell lines as pure ATL cell populations. Here, we report that IL\u20102\u2010dependent ATL cell lines also express IL\u20104R\u03b1 and respond to IL\u20104, which was verified by the activation of cytoplasmic transcriptional activator Stat6 protein. Moreover, a novel ATL cell line that grows stably in an IL\u20107\u2010dependent manner was established from one of the cell lines, and IL\u20107 induced Stat5 activation in this cell line. These results indicated that ATL cells have the potential to express all \u03b3c\u2010receptors except IL\u20109R. Overlapping and switching of cytokine receptors supported the idea that ATL cells can rapidly select the appropriate \u03b3c\u2010receptor according to conditions.<\/jats:p>","DOI":"10.1034\/j.1600-0609.2002.00653.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T18:53:10Z","timestamp":1047408790000},"page":"362-369","source":"Crossref","is-referenced-by-count":10,"title":["Multiple \u03b3c\u2010receptor expression in adult T\u2010cell leukemia"],"prefix":"10.1111","volume":"68","author":[{"given":"Hirofumi","family":"Baba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihisa","family":"Hayashibara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Harasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuto","family":"Tsuruda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyuki","family":"Sugahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Soda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Takasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Tawara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Hirakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Tomonaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimeru","family":"Kamihira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,9,13]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8266076"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8266077"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/7.1.115"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06576.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118138"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113152"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1989.tb01672.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.3.759"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.5.1853"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199609093442"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111992"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1182\/blood.V72.4.1182.1182","article-title":"Leukemic cells from some adult T\u2010cell leukemia patients proliferate in response to interleukin\u20104","volume":"72","author":"Uchiyama T","year":"1988","journal-title":"Blood"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1993.tb00081.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1182\/blood.V91.11.4265","article-title":"Interleukin\u201015 (IL\u201015) can replace the IL\u20102 signal in IL\u20102\u2010dependent adult T\u2010cell leukemia (ATL) cell lines: expression of IL\u201015 receptors on ATL cells","volume":"91","author":"Yamada Y","year":"1998","journal-title":"Blood"},{"key":"e_1_2_5_16_2","first-page":"571","article-title":"Stimulation of B\u2010cell progenitors by cloned murine interleukin\u20107. 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