{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:58:53Z","timestamp":1790099933160,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,4,29]],"date-time":"2002-04-29T00:00:00Z","timestamp":1020038400000},"content-version":"vor","delay-in-days":87,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold> Haemoglobin Lepore\u2010Hollandia is an extremely rare condition in which a small deletion gives rise to a \u03b4\u03b2 hybrid, \u03b2\u2010like globin. There are two single reports of patients from South Pacific Islands and Bangladesh. We describe a family from central Thailand, in which this Hb Lepore\u2010Hollandia interacts with a common \u03b2 globin variant (\u03b2<jats:sup>E<\/jats:sup> resulting from the codon 26, G\u2192A mutation) and \u03b1<jats:sup>+<\/jats:sup> thalassaemia (\u2212\u03b1<jats:sup>3.7<\/jats:sup>). This intriguing interaction caused a troublesome diagnosis, as the two proband brothers were diagnosed as having Hb E\/\u03b2 thalassaemia. Molecular analysis of genomic DNA performed in this study allowed the definitive diagnosis of this complicated interaction. Such studies are required in the diagnosis of thalassaemia and haemoglobinopathies for particular regions like South\u2010east Asia, where many different genotypes may give rise to haemoglobin disorders.<\/jats:p>","DOI":"10.1034\/j.1600-0609.2002.01637.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T18:52:16Z","timestamp":1047408736000},"page":"107-111","source":"Crossref","is-referenced-by-count":26,"title":["Complex interactions of \u03b4\u03b2 hybrid haemoglobin (Hb Lepore\u2010Hollandia) Hb E (\u03b2<sup>26\u2003G\u2192A<\/sup>) and \u03b1<sup>+<\/sup> thalassaemia in a Thai family"],"prefix":"10.1111","volume":"68","author":[{"given":"Vip","family":"Viprakasit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parichat","family":"Pung\u2010Amritt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lerlugh","family":"Suwanthon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Voravarn S.","family":"Tanphaichitr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,4,29]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"A Syllabus of Human Hemoglobin Variants","author":"Huisman 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