{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:13:49Z","timestamp":1785338029299,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T00:00:00Z","timestamp":1032393600000},"content-version":"vor","delay-in-days":80,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold> Acute megakaryocytic leukemia (AmegL) corresponds to 5.0\u201310.0% of all acute myeloid leukemias (AML). Blast crisis as the first presentation of chronic myeloid leukemia (CML) accounts for 10.0% of all cases. <jats:italic>Objective<\/jats:italic>: We report a case of megakaryocytic blast crisis as the first presentation of CML. <jats:italic>Case report<\/jats:italic>: A 25\u2010yr\u2010old\u2010female with a 2\u2010month history of dry cough and a large, non\u2010tender splenomegaly was found to have a hemoglobin concentration of 10.5\u2003g\/dL, a hematocritof 33.0%, a white blood cell count (WBC) of 11.4\u2003\u00d7\u200310<jats:sup>6<\/jats:sup>\u2003L with 38% small blasts, eosinophilia of 5%, basophilia of 8%, and a platelet count of 580\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\u2003L. Bone marrow aspiration revealed 24% of blast cells with cytoplasmatic blebs and hyperplastic megakaryocytic lineage with dysplasia. Cytochemical stains were all negative, immunophenotyping studies showed CD41 and CD61 positivity in blast cells. Bone marrow biopsy showed grade II fibrosis. Karyotype revealed 46,\u2003XX,\u2003t(9,22)\u2003(q34.1;q11.2)[20] and the reverse\u2010transcriptase\u2010PCR (RT\u2010PCR) gave rise a product with a size corresponding to the 210\u2003kDa protein (p210). No matched donor was found. After induction therapy 5.9% of blast cells persisted. The patient received Imatinib Mesylate and is doing well after a 12\u2010month follow\u2010up. <jats:italic>Discussion<\/jats:italic>: AmegL as the first presentation of CML is a rare and often fatal event. Some characteristics point towards the diagnosis of a blast crisis instead of AmegL <jats:italic>de novo<\/jats:italic> with t(9,22).<\/jats:p>","DOI":"10.1034\/j.1600-0609.2002.01638.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T18:53:10Z","timestamp":1047408790000},"page":"58-61","source":"Crossref","is-referenced-by-count":16,"title":["Megakaryocytic blast crisis as a first presentation of chronic myeloid leukemia"],"prefix":"10.1111","volume":"69","author":[{"given":"Luis Arthur","family":"Flores Pelloso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ot\u00e1vio Cesar","family":"Guimar\u00e3es Baiocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lourdes 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