{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:47:56Z","timestamp":1793468876634,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T00:00:00Z","timestamp":1032393600000},"content-version":"vor","delay-in-days":80,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold>  <jats:italic>Objectives<\/jats:italic>\n          : Mantle cell lymphoma (MCL) is characterised by translocation t(11;14) (q13;q32) leading to rearrangement of bcl1\/CCND1 and overexpression of the cell\u2010cycle regulatory protein cyclin D1. We assessed the significance of the cell proliferation rate as an outcome predictor with the five components of the International Prognostic Index (IPI) and the histological subtypes of MCL. \n          <jats:italic>Patients and methods<\/jats:italic>\n          : The hospital case records and histopathological material of 127 patients diagnosed with MCL in a single centre were reviewed. The cell proliferation rate was assessed by Ki\u201067 immunostaining and mitosis counting. Cox's multivariate regression model was used in multivariate survival analyses. The median follow\u2010up time was 87\u2003months. \n          <jats:italic>Results<\/jats:italic>\n          : The mantle zone\/nodular subtype of the common variant (19%) was associated with median survival of 70\u2003months, the diffuse subtype of the common variant (64%) of 35\u2003months, and the blastoid subtype (17%) of 11\u2003months (\n          <jats:italic>P<\/jats:italic>\n          \n            \u200a&lt;\u200a0.001). Patients with Ki\u201067 expression in \u2265\u200a26% (the upper tertile) of the lymphoma cells had median survival of only 13\u2003months as compared with 45\u2003months in the rest of the patients (\n          <jats:italic>P<\/jats:italic>\n          \n            \u200a&lt;\u200a0.001). In a multivariate analysis high Ki\u201067 expression, Ann Arbor stage III\u2013IV, and age over 60\u2003yr had independent influence on survival, whereas serum lactate dehydrogenase level, the number of extranodal disease sites, and performance status did not. \n          <jats:italic>Conclusions<\/jats:italic> : The IPI may not be an optimal tool for outcome prediction in MCL, and a better prognostic index may be obtained by including Ki\u201067 expression and possibly the histological subtype in the index.<\/jats:p>","DOI":"10.1034\/j.1600-0609.2002.01677.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T18:53:10Z","timestamp":1047408790000},"page":"11-20","source":"Crossref","is-referenced-by-count":89,"title":["Ki\u201067 expression level, histological subtype, and the International Prognostic Index as outcome predictors in mantle cell lymphoma"],"prefix":"10.1111","volume":"69","author":[{"given":"Riikka","family":"R\u00e4ty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaarle","family":"Franssila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Joensuu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse","family":"Teerenhovi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkki","family":"Elonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,9,19]]},"reference":[{"key":"e_1_2_17_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199207000-00001"},{"key":"e_1_2_17_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_17_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058904"},{"key":"e_1_2_17_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.6.1570.bloodjournal8561570"},{"key":"e_1_2_17_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870020310"},{"key":"e_1_2_17_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.2.493.493"},{"key":"e_1_2_17_8_2","first-page":"s78","article-title":"Mantle 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