{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:13:55Z","timestamp":1762100035199},"reference-count":30,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2002,12,9]],"date-time":"2002-12-09T00:00:00Z","timestamp":1039392000000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold>  <jats:italic>Objectives<\/jats:italic>\n          : Pre\u2010eclampsia is associated with changes in the hemostatic system and endothelial status. Urinary 11\u2010dehydrothromboxane B\n          <jats:sub>2<\/jats:sub>\n          \n            \/creatinine (11\u2010DTXB\n          <jats:sub>2<\/jats:sub>\n          \n            \/Cr) is a marker for platelet activation and vascular constriction, thrombin\u2013antithrombin complex (TAT) for thrombin formation, serum thrombomodulin (TM) for endothelial damage, and \u03b2\u2010thromboglobulin \n          (\u03b2\u2010TG) and platelet factor 4 (PF\u20104) for platelet activation and releasing reaction. The present study attempted to evaluate these five markers in normotensive pregnancy and pre\u2010eclampsia. <jats:italic>Methods<\/jats:italic>: These five markers were simultaneously measured in urine and blood samples from 25 women who were not pregnant (group 1, controls), 31 women with normotensive pregnancy (group 2, second controls), 22 women with mild pre\u2010eclampsia (group 3), and 21 women with severe pre\u2010eclampsia (group 4). The average gestational age was 36\u2003wk. <jats:italic>Results<\/jats:italic>: The 11\u2010DTXB<jats:sub>2<\/jats:sub>\/Cr, TAT, and \u03b2\u2010TG levels were significantly higher (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01) in groups 2, 3, and 4 than in group 1. The TM and \u03b2\u2010TG levels were significantly higher (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) in group 3 than in group 2. The TM, \u03b2\u2010TG, and PF\u20104 levels were increased significantly (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05\u20130.01) in group 4 compared to those in groups 1, 2, and 3. <jats:italic>Conclusions<\/jats:italic>: Platelet aggregation, vascular constriction, and thrombin formation (detected by 11\u2010DTXB<jats:sub>2<\/jats:sub>\/Cr and TAT) may be markedly enhanced even in group 2, but further enhancement may be relatively slight in groups 3 and 4. In contrast, endothelial damage (determined by TM) and platelet release of PF\u20104 may not increase significantly in group 2, but they may increase in group 4. Platelet\u2010release of \u03b2\u2010TG may be enhanced in groups 2, 3, and 4. Endothelial damage and platelet\u2010releasing reaction (detected by PF\u20104 and \u03b2\u2010TG) may be significantly more enhanced in group 4 than in group 3.<\/jats:p>","DOI":"10.1034\/j.1600-0609.2002.02691.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T18:53:57Z","timestamp":1047408837000},"page":"297-302","source":"Crossref","is-referenced-by-count":31,"title":["Characterization of five marker levels of the hemostatic system and endothelial status in normotensive pregnancy and 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