{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:17:01Z","timestamp":1791346621520,"version":"4.3.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,9,13]],"date-time":"2002-09-13T00:00:00Z","timestamp":1031875200000},"content-version":"vor","delay-in-days":104,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Homozygous sickle cell anaemia (SS disease) involves a high prevalence of skin ulcerations, and background experience concerning the cutaneous microcirculatory flux and reactivity in this disease is very limited. We investigated, by laser\u2010Doppler velocimetry, the microcirculatory cutaneous blood flow and vasoreactivity in 17 patients with SS disease but no cutaneous trophic changes, vs. the corresponding values in 18 normal matched controls. The laser\u2010Doppler probe was placed on the foot dorsum, and recordings were made in the supine and dependent positions, and after post\u2010ischaemic hyperaemia. The venoarteriolar reflex was calculated as the difference between the fluxes in the supine and dependent positions. In both positions, patients with SS disease exhibited clear vasodilation, with larger cutaneous fluxes than those of the controls (<jats:italic>P<\/jats:italic>=0.024 and 0.0009, respectively). The venoarteriolar reflex, expressed as a percentage of the resting supine flux, was lower in the patients (<jats:italic>P<\/jats:italic>=0.0004). These impairments of the microcirculatory fluxes, which combine a vasodilated state with abnormal vasoreactivity, resemble those observed in patients with chronic venous insufficiency and might be crucial in determining the pathogenesis of the skin ulcerations that occur in SS disease. Laser\u2010Doppler velocimetry seems a suitable non\u2010invasive technique for investigating such cutaneous microangiopathy.<\/jats:p>","DOI":"10.1034\/j.1600-0609.2002.02701.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T18:53:10Z","timestamp":1047408790000},"page":"327-331","source":"Crossref","is-referenced-by-count":17,"title":["Cutaneous microvascular blood flow and reactivity in patients with homozygous sickle cell anaemia"],"prefix":"10.1111","volume":"68","author":[{"given":"Pierre Louis","family":"Tharaux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Girot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Kanfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean 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