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This article reviews both the molecular mechanisms working in AICD and the role played by such mechanisms in preventing a number of skin diseases. Specifically, because AICD removes activated and autoreactive T cells through a CD95\u2010\/CD95\u2010L\u2010mediated suicide, skin diseases were scrutinized in which such valuable machinery could be lacking. Indeed, at least some inflammatory skin diseases, including psoriasis and atopic dermatitis, can be sustained by an increased survival of activated T lymphocytes associated with deficient CD95\u2010\/CD95\u2010L\u2010mediated AICD of such strong pro\u2010inflammatory cells. In addition, autoreactive skin diseases, including, e.g. alopecia areata, lichen planus and other lichenoid tissue reactions, can be related to autoreactive T lymphocytes which could be unable to undergo CD95\u2010\/CD95\u2010L\u2010mediated AICD. Finally, a lack of AICD may be executive even in favoring cutaneous T cell lymphoma. Thus, because inflammatory, autoreactive and neoplastic skin diseases can be associated with a deficient CD95\u2010\/CD95\u2010L\u2010mediated suicide of activated T cells, AICD is likely to represent a fundamental program to preserve the homeostasis of the skin. Therapeutic approaches able to restore the AICD machinery promise to successfully treat such relevant skin diseases.<\/jats:p>","DOI":"10.1034\/j.1600-0625.2002.110101.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T20:27:17Z","timestamp":1047414437000},"page":"1-11","source":"Crossref","is-referenced-by-count":9,"title":["\u2018Activation\u2010induced cell death\u2019: a special program able to preserve the homeostasis of the skin?"],"prefix":"10.1111","volume":"11","author":[{"given":"Giuseppe","family":"De Panfilis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,4,21]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"413","article-title":"Apoptosis and the skin","volume":"11","author":"Teraki Y","year":"1999","journal-title":"Eur J Dermatol"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00037.x"},{"key":"e_1_2_8_4_2","first-page":"243","volume":"11","author":"Weedon D","year":"1990","journal-title":"Apoptosis. 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