{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:20:00Z","timestamp":1758979200006},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,8,20]],"date-time":"2002-08-20T00:00:00Z","timestamp":1029801600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold> There is a strong need for antipruritic substances for treating itch in clinical dermatology. In one recent human study, topically applied acetylsalicylic acid has been described to rapidly decrease histamine\u2010induced itch. We have established a model for periferally elicited pruritus by injecting serotonin into the rostral back area (neck) in rats. Using this model, we aimed to investigate the antipruritic potential of four different salicylic compounds, which all possess different skin penetration characteristics. Eighteen rats were studied for 6\u2003weeks. Prior to serotonin injections (2\u2003mg\/ml, 50\u2003\u00b5l), 10\u2003\u00b5l of test substances was applied to a circular area 18\u2003mm in diameter. The four substances were salicylic acid, butyl salicylate, diethylamine salicylate and salicylamide, all solubilized in dimethyl isosorbide to a concentration of 5% w\/w. Diethylamine salicylate and salicylamide were previously shown to be slowly absorbed through rat skin in contrast to salicylic acid and butyl salicylate. After serotonin injections, scratching was monitored by video recording for 1.5\u2003h. Compared with the vehicle, a lower number of scratch sequences were seen when diethylamine salicylate (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and salicylamide (<jats:italic>P<\/jats:italic>\u2003=\u20030.005) had been applied. The numbers of scratch sequences were lower with diethylamine salicylate and salicylamide than with the vehicle throughout the 1.5\u2010h study period. We conclude that topical application of diethylamine salicylate and salicylamide could suppress serotonin\u2010induced scratching in rats. The antipruritic effect seems to be related to the slow drug release of the two substances. The results may be clinically relevant as serotonin induces itch in humans.<\/jats:p>","DOI":"10.1034\/j.1600-0625.2002.110412.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T20:27:52Z","timestamp":1047414472000},"page":"370-375","source":"Crossref","is-referenced-by-count":15,"title":["The effect of topically applied salicylic compounds on serotonin\u2010induced scratching behaviour in hairless rats"],"prefix":"10.1111","volume":"11","author":[{"given":"J.\u2003S.","family":"Thomsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Simonsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Benfeldt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2003B.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Serup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,8,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2340\/0001555559505512","article-title":"Pruritus in polycythemia vera: treatment with aspirin and possibility of platelet involvement","volume":"59","author":"Fjellner B","year":"1979","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2340\/0001555553363368","article-title":"Influence of antihistamines, sedatives, and aspirin on experimental itch","volume":"53","author":"Hagermark O","year":"1973","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.293.6552.907"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2340\/0001555577046048","article-title":"Topically applied aspirin rapidly decreases histamine\u2010induced itch","volume":"77","author":"Yosipovitch G","year":"1997","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00011-G"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12868-8"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00155-7"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01327-6"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00452.x"},{"key":"e_1_2_7_11_2","unstructured":"SimonsenL TherkildsenJ J\u00f8rgensenA.In vitropermeation and metabolism of salicylic compounds in hairless rat skin.Int J Pharm2002(in press)."},{"key":"e_1_2_7_12_2","unstructured":"SimonsenL.Percutaneous absorption of salicylic compounds. A comparison of skin penetration\/permeation techniques.Thesis 2001 University of Copenhagen Faculty of Health Sciences."},{"key":"e_1_2_7_13_2","unstructured":"ThomsenJ S.Itch models and effect of topical antipruritic substances.Thesis 2001 University of Copenhagen Faculty of Health Sciences."},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/00015550152572868"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050447"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02859.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1998.00045.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050213"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1085-5629(05)80052-5"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000044967"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0625.2002.110412.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0625.2002.110412.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0625.2002.110412.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T08:25:04Z","timestamp":1695889504000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0625.2002.110412.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["10.1034\/j.1600-0625.2002.110412.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0625.2002.110412.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8]]}}}