{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:29:26Z","timestamp":1768069766998,"version":"3.49.0"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,9,9]],"date-time":"2003-09-09T00:00:00Z","timestamp":1063065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Stress has long been suspected as a possible cause of hair loss in various species, even though convincing experimental evidence has not been available. Recently, we have shown in a murine model that sonic stress alters hair growth and cycling <jats:italic>in vivo<\/jats:italic>, and have postulated the existence of a \u2018brain\u2010hair follicle axis\u2019 (BHA). In order to study whether a clinically available and widely used topically active hair growth stimulator mitigates stress\u2010triggered hair growth inhibition in this stress model, we have applied a 5% minoxidil solution. Female CBA\/J mice were depilated and randomized in to two groups: control (n\u2003=\u200320) and sonic stress (n\u2003=\u200320). These groups were further divided and either treated daily with 5% minoxidil solution or vehicle alone. The stress group was exposed to sonic stress for 24\u2003h starting 14\u2003days after anagen induction by depilation. All mice were sacrificed 16\u2003days after the depilation and assessed by quantitative histomorphometry. Sonic stress significantly increased the number of hair follicles with apoptotic cells and inhibited intrafollicular keratinocyte proliferation. In addition, the number of clusters of perifollicular MHC class II+ cells and degranulated perifollicular mast cells was significantly enhanced in the stressed mice. In accordance with previous findings, all stressed mice showed an advanced hair cycle progression towards catagen. All of these stress\u2010induced hair growth inhibitory changes along the BHA were down\u2010regulated by topical minoxidil application. This encourages one to explore clinically whether topical minoxidil is a safe and effective pharmacologic tool for the management of stress\u2010associated telogen effluvium in humans.<\/jats:p>","DOI":"10.1034\/j.1600-0625.2003.00028.x","type":"journal-article","created":{"date-parts":[[2003,9,9]],"date-time":"2003-09-09T08:46:53Z","timestamp":1063097213000},"page":"580-590","source":"Crossref","is-referenced-by-count":29,"title":["Topical minoxidil counteracts stress\u2010induced hair growth inhibition in mice"],"prefix":"10.1111","volume":"12","author":[{"given":"Petra Clara","family":"Arck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bori","family":"Handjiski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva M. J.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelin","family":"Hagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burghard F.","family":"Klapp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Paus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,9,9]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1","volume-title":"Major Problems in Dermatology","author":"Whitlock F A","year":"1976"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.2466\/PR0.82.3.1044-1046"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1999.tb02063.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00003.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.1997.13"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2001.100507-8.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0699fje"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1993.tb00579.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.8755-8920.2001.450506.x"},{"key":"e_1_2_6_11_2","first-page":"281","article-title":"The coat of the mouse (Mus musculus)","volume":"165","author":"Dry F W","year":"1926","journal-title":"J Genet"},{"key":"e_1_2_6_12_2","first-page":"435","volume-title":"The Biology of Hair Growth.","author":"Chase H B","year":"1953"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01377.x"},{"key":"e_1_2_6_14_2","first-page":"134","article-title":"Hair growth induction by substance P","volume":"71","author":"Paus R","year":"1994","journal-title":"Lab Invest"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1994.1139"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00791.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01232.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1997.tb03685.x"},{"key":"e_1_2_6_19_2","first-page":"314","article-title":"Hair inervation and vasculature","volume":"8","author":"Hordinsky M K","year":"1999","journal-title":"Exp Dermatol"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03036.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.14.5.752"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03784.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(94)90205-4"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90066-7"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb09006.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.8755-8920.2001.460201.x"},{"key":"e_1_2_6_27_2","first-page":"343","article-title":"The impact of skin disease on the quality of life of adolescents","volume":"12","author":"Smith J A","year":"2001","journal-title":"Adolesc Med"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198012183032516"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161010-00006"},{"key":"e_1_2_6_30_2","first-page":"35","article-title":"Management of male pattern hair loss","volume":"68","author":"Sinclair R D","year":"2001","journal-title":"Cutis"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12277095"},{"key":"e_1_2_6_32_2","first-page":"1601","article-title":"Analysis of apoptosis during hair follicle regression","volume":"151","author":"Lindner G","year":"1997","journal-title":"Am J Pathol"},{"key":"e_1_2_6_33_2","first-page":"1433","article-title":"Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition of massive catagen development, and relative protection from chemotherapy\u2010induced alopecia","volume":"150","author":"Maurer M","year":"1997","journal-title":"Am J Pathol"},{"key":"e_1_2_6_34_2","first-page":"319","article-title":"Activated skin mast cells are involved in murine hair follicle regression (catagen)","volume":"77","author":"Maurer M","year":"1997","journal-title":"Lab Invest"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215549804600310"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod53.4.814"},{"key":"e_1_2_6_37_2","first-page":"1178","article-title":"The role of CD4+ lymphocytes in the susceptibility of mice to stress\u2010induced reactivation of experimental colitis","volume":"10","author":"Qui B S","year":"1999","journal-title":"Nat Med"},{"key":"e_1_2_6_38_2","first-page":"523","article-title":"A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis","volume":"13","author":"Paus R","year":"1999","journal-title":"J Invest Dermatol"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1995.tb00256.x"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1159\/000319288"},{"key":"e_1_2_6_41_2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1001\/archderm.1983.01650300055017","article-title":"Psychosomatic concepts in dermatology. A dermatologist\u2010psychoanalyst's viewpoint","volume":"119","author":"Koblenzer C S","year":"1983","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_42_2","volume-title":"Diseases of the Hair and Scalp","author":"Dawber R","year":"1997"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90958-6"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-202X(93)90496-5"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.1.449"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1995.54"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12334249"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12611409"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1995.tb00252.x"},{"key":"e_1_2_6_50_2","first-page":"937","article-title":"Mast cell granule composition and tissue location \u2013 a close correlation","volume":"15","author":"Beil W J","year":"2000","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050195"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1159\/000051732"},{"key":"e_1_2_6_53_2","first-page":"736","article-title":"Potassium channel openers antagonize 4\u2010aminopyridine induced histamine release from rat peritoneal mast cells. [Article in Chinese]","volume":"30","author":"Chen Z G","year":"1995","journal-title":"Yao Xue Xue Bao"},{"key":"e_1_2_6_54_2","first-page":"888","article-title":"The anti\u2010anaphylactic action of potassium channel openers and its mechanism. [Article in Chinese]","volume":"32","author":"Wang P","year":"1997","journal-title":"Yao Xue Xue Bao"},{"key":"e_1_2_6_55_2","first-page":"190","article-title":"An experimental study evaluating the effect of minoxidil on the growth cycle of hair follicles","volume":"69","author":"Gobe G C","year":"1989","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(97)00068-6"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70082-6"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70387-9"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0625.2003.00028.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0625.2003.00028.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0625.2003.00028.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T05:42:54Z","timestamp":1697348574000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0625.2003.00028.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,9]]},"references-count":57,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["10.1034\/j.1600-0625.2003.00028.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0625.2003.00028.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9,9]]}}}