{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:29:41Z","timestamp":1791044981740,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,4,16]],"date-time":"2003-04-16T00:00:00Z","timestamp":1050451200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold> CD44 is a family of cell\u2010surface receptors on human lymphocytes that act as co\u2010stimulatory molecules leading to the induction of effector functions in T cells. We have analyzed primary cutaneous malignant melanomas with clinical and histologic signs of tumor regression using immunohistochemistry and observed the predominant expression of the CD44 variant isoform v10 on CD3 CD4\/CD8 co\u2010expressing tumor\u2010infiltrating lymphocytes (TIL). We further analyzed the role of CD44v10 in adhesion of lymphocytes to human melanoma cells. In contrast to CD44<jats:sup>\u2013<\/jats:sup> lymphatic cells, CD44v10<jats:sup>+<\/jats:sup> lymphatic cells strongly bound to cultured human melanoma cells and to frozen tissue samples of melanomas. Antibody blocking studies revealed a hyaluronan\u2010, integrin\u2010, and selectin\u2010independent pathway of adhesion. Furthermore, CD44v10<jats:sup>+<\/jats:sup> lymphatic cells exhibited significantly higher invasiveness in three\u2010dimensional collagen matrices as compared with CD44H<jats:sup>+<\/jats:sup> and CD44\u2010negative lymphocytes. These results indicate that expression of CD44v10 on TIL may mediate adhesion to melanoma cells and result in gain of novel invasive properties.<\/jats:p>","DOI":"10.1034\/j.1600-0625.2003.00044.x","type":"journal-article","created":{"date-parts":[[2004,12,23]],"date-time":"2004-12-23T11:31:04Z","timestamp":1103801464000},"page":"204-212","source":"Crossref","is-referenced-by-count":11,"title":["CD44 variant isoform v10 is expressed on tumor\u2010infiltrating lymphocytes and mediates hyaluronan\u2010independent heterotypic cell\u2013cell adhesion to melanoma cells"],"prefix":"10.1111","volume":"12","author":[{"given":"T. K.","family":"Weimann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Goos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. N.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,4,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/00313027509092702"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.4.272"},{"key":"e_1_2_6_4_2","first-page":"77","article-title":"In situ analysis of the mononuclear cell infiltrate in primary malignant melanoma of the skin","volume":"51","author":"Poppema S","year":"1983","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00370715"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117116"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118790"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(00)01622-4"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/08830189909088485"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.15.1159"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.4049\/jimmunol.152.7.3501","article-title":"Treatment of established lung metastases with tumor\u2010infiltrating lymphocytes derived from a poorly immunogenic tumor engineered to secrete human TNF\u2010alpha","volume":"152","author":"Marincola F M","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.1.249"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5258.60"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.003511"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12874977"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s000180050183"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.159.6.2549"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5338.672"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.3.1119"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1996.tb00087.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.2.497"},{"key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.4049\/jimmunol.143.8.2457","article-title":"Dual role of the CD44 molecule in T cell adhesion and activation","volume":"143","author":"Shimizu Y","year":"1989","journal-title":"J Immunol"},{"key":"e_1_2_6_23_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4049\/jimmunol.153.1.21","article-title":"Hyaluronate is costimulatory for human T cell effector functions and binds to CD44 on activated T cells","volume":"153","author":"Galandrini R","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_6_24_2","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.4049\/jimmunol.160.12.5781","article-title":"Cooperation between CD44 and LFA\u20101\/CD11a adhesion receptors in lymphokine\u2010activated killer cell cytotoxicity","volume":"160","author":"Matsumoto G","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.113.1.207"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.116.3.817"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.24.12160"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60537-4"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.128.4.673"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb07955.x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90403-L"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1496383"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.12.2053"},{"key":"e_1_2_6_34_2","first-page":"219","article-title":"CD44 variants but not CD44s cooperate with beta1\u2010containing integrins to permit cells to bind to osteopontin independently of arginine\u2010glycine\u2010aspartic acid, thereby stimulating cell motility and chemotaxis","volume":"59","author":"Katagiri Y U","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00302.x"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01467.x"},{"key":"e_1_2_6_37_2","first-page":"541","article-title":"Immune response against human primary malignant melanoma: a distinct cytokine mRNA profile associated with spontaneous regression","volume":"78","author":"Wagner S N","year":"1998","journal-title":"Laboratory Invest"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.144.3.828"},{"key":"e_1_2_6_39_2","doi-asserted-by":"crossref","first-page":"6002","DOI":"10.4049\/jimmunol.154.11.6002","article-title":"Tumor endothelium selectively supports binding of IL\u20102\u2010propagated tumor\u2010infiltrating lymphocytes","volume":"154","author":"Salmi M","year":"1995","journal-title":"J Immunol"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(91)90511-5"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.108.6.2435"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90279-8"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90337-9"},{"key":"e_1_2_6_44_2","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.4049\/jimmunol.158.4.1610","article-title":"Function of lymphocyte homing\u2010associated adhesion molecules on human natural killer and lymphokine\u2010activated killer cells","volume":"158","author":"Uksila J","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.20.14939"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8692"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12472106"},{"key":"e_1_2_6_48_2","volume-title":"Fundamental immunology.","author":"Butcher E C","year":"1989"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90694-A"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3430071"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.4.859"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60101-3"},{"key":"e_1_2_6_53_2","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.4049\/jimmunol.145.11.3589","article-title":"Triggering of the CD44 antigen on T lymphocytes promotes T cell adhesion through the LFA\u20101 pathway","volume":"145","author":"Koopman G","year":"1990","journal-title":"J Immunol"},{"key":"e_1_2_6_54_2","first-page":"4427","article-title":"CD44 stimulation induces integrin\u2010mediated adhesion of colon cancer cell lines to endothelial cells by up\u2010regulation of integrins and c\u2010Met and activation of integrins","volume":"59","author":"Fujisaki T","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_6_55_2","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.4049\/jimmunol.162.4.2391","article-title":"Cross\u2010linking of CD44 on rheumatoid synovial cells up\u2010regulates VCAM\u20101","volume":"162","author":"Fujii K","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.135.4.1139"},{"key":"e_1_2_6_57_2","doi-asserted-by":"crossref","first-page":"6304","DOI":"10.1016\/S0021-9258(18)88971-2","article-title":"Isolation of dermatan sulfate proteoglycans from mature bovine articular cartilages","volume":"260","author":"Rosenberg L C","year":"1985","journal-title":"J Biol Chem"},{"key":"e_1_2_6_58_2","doi-asserted-by":"crossref","first-page":"8012","DOI":"10.1016\/S0021-9258(18)83143-X","article-title":"Regulation of cell\u2010substrate adhesion by proteoglycans immobilized on extracellular substrates","volume":"264","author":"Yamagata M","year":"1989","journal-title":"J Biol Chem"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.116.2.521"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1999.4391"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06704.x"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0625.2003.00044.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0625.2003.00044.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0625.2003.00044.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T18:03:20Z","timestamp":1697220200000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0625.2003.00044.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["10.1034\/j.1600-0625.2003.00044.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0625.2003.00044.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}