{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:51:34Z","timestamp":1789815094622,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,11,24]],"date-time":"2002-11-24T00:00:00Z","timestamp":1038096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold>  <jats:italic>Background\/Aims: <\/jats:italic>Uncoupling proteins are thought to protect cells from oxidative stresses. Because uncoupling protein\u20102 is expressed in liver and reactive oxygen species are involved in pathogenesis of various liver diseases, this protein may protect liver cells from disease\u2010associated oxidative stress. However, uncoupling protein\u20102 expression in human liver has not been examined. <jats:italic>Methods: <\/jats:italic>We investigated hepatic uncoupling protein\u20102 distribution in various liver diseases including primary biliary cirrhosis, autoimmune hepatitis, chronic viral hepatitis, and histologically normal liver by immunohistochemistry.<jats:italic>Results: <\/jats:italic>Uncoupling protein\u20102 was expressed in some hepatocytes, however, the degree of hepatocytic uncoupling protein\u20102 expression did not differ significantly among liver diseases and normal liver. Uncoupling protein\u20102 was abundant in biliary epithelial cells in primary biliary cirrhosis but not in other liver specimens. Enhanced uncoupling protein\u20102 expression in biliary epithelial cells was specific for primary biliary cirrhosis and did not result simply from cholestasis. The percentage of uncoupling protein\u20102 positive bile ducts in primary biliary cirrhosis patients treated with ursodeoxycholic acid was significantly lower than in untreated patients.<jats:italic>Conclusions: <\/jats:italic>These results suggest that uncoupling protein\u20102 is involved in the pathogenesis of primary biliary cirrhosis.<\/jats:p>","DOI":"10.1034\/j.1600-0676.2002.01700.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T10:24:45Z","timestamp":1047464685000},"page":"451-458","source":"Crossref","is-referenced-by-count":9,"title":["Expression of uncoupling protein\u20102 in biliary epithelial cells in primary biliary 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