{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:54:01Z","timestamp":1791176041215,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,1,28]],"date-time":"2003-01-28T00:00:00Z","timestamp":1043712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold><jats:bold> Aim:<\/jats:bold> To evaluate 5\u2010year survival predictive factors in hospitalised patients with excessive alcohol intake and cirrhosis, including in a multivariate analysis the severity of the liver disease, gastrointestinal bleeding, concomitant viral B or C infection, smoking status, presence of alcoholic hepatitis at inclusion and abstinence from alcohol during follow\u2010up.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> In a non\u2010concurrent cohort study, 122 patients with excessive alcohol intake and cirrhosis were followed up at least five years or till death. Two patients were lost to follow\u2010up. <jats:italic>Results:<\/jats:italic> The 5\u2010year survival rates were 43% in the 122 patients and 66%, 50% and 25% in Child\u2013Pugh class A, B and C patients, respectively. In multivariate analysis, age (<jats:italic>P<\/jats:italic>\u2003=\u20030.01), Child\u2013Pugh score (<jats:italic>P<\/jats:italic>\u2003=\u20030.0001), gastrointestinal bleeding (<jats:italic>P<\/jats:italic>\u2003=\u20030.01), presence of HBs Ag and\/or anti\u2010HCV (<jats:italic>P<\/jats:italic>\u2003=\u20030.03), smoking (<jats:italic>P<\/jats:italic>\u2003=\u20030.01), absence of histologically proven alcoholic hepatitis (<jats:italic>P<\/jats:italic>\u2003=\u20030.05) and persistent alcohol intake (<jats:italic>P<\/jats:italic>\u2003=\u20030.002) were associated with significantly increased risk ratios of death.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> In hospitalised patients with excessive alcohol intake and cirrhosis: (1) age, liver failure, gastrointestinal bleeding, concomitant viral B or C infection and persistent alcohol intake are independent poor prognostic markers, (2) smoking may contribute to the aggravation of cirrhosis, and (3) alcoholic hepatitis, being a potentially reversible cause of liver failure, has a favourable prognostic significance.<\/jats:p>","DOI":"10.1034\/j.1600-0676.2003.01804.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T10:24:47Z","timestamp":1047464687000},"page":"45-53","source":"Crossref","is-referenced-by-count":216,"title":["Five\u2010year survival predictive factors in patients with excessive alcohol intake and cirrhosis. 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