{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:07:19Z","timestamp":1760170039580},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,12,9]],"date-time":"2002-12-09T00:00:00Z","timestamp":1039392000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold> Evaluation of cellular immunity in the intestinal lamina propria of rhesus macaques has been used previously to assess protective immunity against mucosal simian immunodeficiency virus (SIV) challenges. As this technique requires survival surgery to obtain jejunal tissue, effects of surgical stress on the immune system were investigated. SIV\u2010specific immune responses, including IgG and IgA binding antibodies in sera and mucosal secretions, IgG and IgA secreting cells in peripheral blood, IgG neutralizing antibodies, T\u2010cell proliferative responses, and interferon\u2010<jats:italic>\u03b3<\/jats:italic> secretion by peripheral blood mononuclear cells, were evaluated pre\u2010 and post\u2010surgery in macaques immunized with adenovirus\u2010SIV recombinant vaccines and SIV envelope protein and in SIV\u2010infected macaques. No differences in these immune parameters were observed in SIV\u2010na\u00efve, immunized macaques or healthy SIV\u2010infected macaques with regard to surgery. A dramatic increase in total IgA antibody level following surgery in the rectal secretions of one SIV\u2010infected macaque that was rapidly progressing to AIDS and failed to recover from surgery was attributed to an abscess that developed at the intestinal site. To date, nearly 30 other macaques have undergone the intestinal survival surgery, some on more than one occasion, without experiencing any clinical difficulty. Overall, our results suggest that in healthy macaques, intestinal resection survival surgery can be conducted safely. Further, the method can be used to reliably sample the intestinal mucosa without major or persistent impact on humoral or cellular immune responses.<\/jats:p>","DOI":"10.1034\/j.1600-0684.2002.01018.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T06:35:46Z","timestamp":1047450946000},"page":"313-322","source":"Crossref","is-referenced-by-count":2,"title":["Effects of intestinal survival surgery on systemic and mucosal immune responses in SIV\u2010infected rhesus macaques"],"prefix":"10.1111","volume":"31","author":[{"given":"Yvette Y.","family":"Edghill\u2010Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine","family":"Aldrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Pinczewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.S.","family":"Kalyanaraman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monae","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliya","family":"Heyliger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Preston Perrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Woodward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjorie","family":"Robert\u2010Guroff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,12,9]]},"reference":[{"key":"e_1_2_15_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1995.11.383"},{"key":"e_1_2_15_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(01)00295-6"},{"key":"e_1_2_15_4_2","doi-asserted-by":"crossref","first-page":"7430","DOI":"10.1128\/JVI.73.9.7430-7440.1999","article-title":"Factors associated with slow disease progression in macaques immunized with an adenovirus\u2010simian immunodeficiency virus (SIV) envelope priming\u2010gp120 boosting regimen and challenged vaginally with SIVmac251","volume":"73","author":"Buge SL","journal-title":"J Virol"},{"key":"e_1_2_15_5_2","doi-asserted-by":"crossref","first-page":"8531","DOI":"10.1128\/jvi.71.11.8531-8541.1997","article-title":"An adenovirus\u2010simian immunodeficiency virus env vaccine elicits humoral, cellular, and mucosal immune responses in rhesus macaques and decreases viral burden following vaginal challenge","volume":"71","author":"Buge SL","year":"1997","journal-title":"J Virol"},{"key":"e_1_2_15_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.11.6721-6727.1992"},{"key":"e_1_2_15_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1997.236-ce1111.x"},{"key":"e_1_2_15_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/095646249500600301"},{"key":"e_1_2_15_9_2","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1093\/ajcn\/21.9.1110","article-title":"Some immunological factors in small intestine disease. 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