{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T13:48:55Z","timestamp":1770472135754,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2002,1,4]],"date-time":"2002-01-04T00:00:00Z","timestamp":1010102400000},"content-version":"vor","delay-in-days":490,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold> Apoptosis appears to be the mode of cell death by which damaged cells are removed from the lesional tissue in oral lichen planus (OLP). In the present study, OLP biopsies were immunohistochemically evaluated for TNF\u2010\u03b1 and apoptosis\u2010regulating proteins in an attempt to compare their phenotypic expression. Deparaffinized tissue sections from 22 OLP and 10 control oral biopsy specimens were immunohistochemically stained with anti\u2010Bcl\u20102, anti\u2010Bcl\u2010x, anti\u2010Bax and anti\u2010TNF\u2010\u03b1 antibodies. Keratinocytes did not show any immunoreactivity for Bcl\u20102, while a uniform intense staining for this protein was evident in the lymphocytic infiltrate of OLP specimens. Immunoreactivity for TNF\u2010\u03b1 was seen in 17\/22 OLP cases. All control tissues were TNF\u2010\u03b1 negative, thus indicating a possible involvement of this cytokine in the pathogenesis of OLP. The differences in the staining intensities of Bcl\u2010x and Bax between OLP and normal epithelium were slight; therefore an obvious association of the phenotypic TNF\u2010\u03b1 expression with these apoptosis\u2010regulating proteins was not apparent.<\/jats:p>","DOI":"10.1034\/j.1600-0714.2000.290802.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T07:44:30Z","timestamp":1047455070000},"page":"370-375","source":"Crossref","is-referenced-by-count":49,"title":["TNF\u2010\u03b1 expression and apoptosis\u2010regulating proteins in oral lichen planus: a comparative immunohistochemical evaluation"],"prefix":"10.1111","volume":"29","author":[{"given":"Alexandra","family":"Sklavounou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evanthia","family":"Chrysomali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Scorilas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Karameris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1,4]]},"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0714.2000.290802.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0714.2000.290802.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0714.2000.290802.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T17:57:38Z","timestamp":1698602258000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0714.2000.290802.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["10.1034\/j.1600-0714.2000.290802.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0714.2000.290802.x","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}