{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T03:23:37Z","timestamp":1773631417967,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,4,30]],"date-time":"2002-04-30T00:00:00Z","timestamp":1020124800000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> In oral lichen planus (OLP), destruction of the basal cell layer, which is one of the characteristic histological features, is seen and many changes in cell proliferation, cell repair and cell death occur in the injured mucosal epithelium.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We studied mucosal tissues from 19 patients of OLP and 10 controls, with immunohistochemistry for Ki\u201067, p53, cyclin dependent kinase inhibitors (CDKI) and cyclins. Mitotic count was calculated. TUNEL assay was also performed for evaluation of apoptotic cell death.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Mitotic count, Ki\u201067 and cyclin D1 labeling indices in the basal and parabasal layers of OLP mucosa were elevated in comparison with those of controls. p53, p21<jats:sup>Cip1<\/jats:sup> and TUNEL indices of OLP mucosa were also increased.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These complex changes, which concomitantly occur in the injured mucosal epithelium, could contribute to the development and maintenance of characteristic mucosal epithelial architectures seen in OLP.<\/jats:p>","DOI":"10.1034\/j.1600-0714.2002.310403.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T07:45:52Z","timestamp":1047455152000},"page":"204-212","source":"Crossref","is-referenced-by-count":41,"title":["Cell proliferation activity and the expression of cell cycle regulatory proteins in oral lichen planus"],"prefix":"10.1111","volume":"31","author":[{"given":"Makoto","family":"Hirota","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Okudela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Kawabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Yazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Nakatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyohide","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,4,30]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1985.tb00516.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(68)90272-7"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1988.tb01527.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1997.tb00453.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1990.tb01676.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/358015a0"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-71941-7_6"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(199812)20:12<1020::AID-BIES8>3.0.CO;2-D"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.290804.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0964-1955(95)00049-6"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(99)70116-2"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004180050321"},{"key":"e_1_2_5_14_2","first-page":"461","article-title":"Analysis of p21Waf1\/Cip1 expression in normal, premalignant cells during the development of human lung adenocarcinoma","volume":"151","author":"Hayashi H","year":"1997","journal-title":"Am J Pathol"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::aid-path653>3.3.co;2-m"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65236-4"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI831"},{"key":"e_1_2_5_18_2","first-page":"505","article-title":"Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines","volume":"55","author":"Shapiro GI","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/38525"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00073-8"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1998.tb01963.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1985.tb00520.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1990.tb00820.x"},{"key":"e_1_2_5_24_2","first-page":"867","article-title":"Immunobiochemical and molecular biologic characterization of the cell proliferation\u2010associated nuclear antigen that is defined by monoclonal antibody Ki\u201067","volume":"138","author":"Gerdes J","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/110.1.24"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0964-1955(96)00068-1"},{"key":"e_1_2_5_27_2","first-page":"9","volume-title":"Cell cycle control","author":"Sheaff RJ","year":"1998"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199801)184:1<83::AID-PATH963>3.0.CO;2-B"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1998.tb01969.x"},{"key":"e_1_2_5_30_2","first-page":"585","article-title":"Reduced levels of the cell cycle inhibitor p27Kip1 in epithelial dysplasia and carcinoma of the oral cavity","volume":"152","author":"Jordan RC","year":"1998","journal-title":"Am J Pathol"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65216-9"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(97)00091-2"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65306-0"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0714.2002.310403.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0714.2002.310403.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0714.2002.310403.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T20:25:29Z","timestamp":1697574329000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0714.2002.310403.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["10.1034\/j.1600-0714.2002.310403.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0714.2002.310403.x","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}