{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:25:38Z","timestamp":1761647138631},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":633,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>Generalised early\u2010onset periodontitis (GEOP) is characterized by acute inflammatory bursts, resulting in rapid destruction of the periodontal apparatus in young adults. An impaired host defense seems to play an improtant role as etilogical factor of periodontitis, especially in the development of GEOP. As the Gram\u2010negative <jats:italic>Porphyromonas gingivalis<\/jats:italic> has been indentified as one of the causative anaerobic bacteria, the humoral immune response to this micro\u2010organism is of particular interest in patients with GEOP. To evaluate the local immune status, we measured total and <jats:italic>P. gingivalis<\/jats:italic>\u2010 reactive salivary IgA in GEOP patients and in age\u2010 and gender\u2010matched periodontally normal controls. We found a significantly lower concentration and secretion rate of total salivary IgA in the GEOP group. Although no differences were detected in the concentration or secretion of <jats:italic>P. gingivalis<\/jats:italic>\u2010reactive IgA  between groups, the specific fraction of <jats:italic>P. gingivalis<\/jats:italic>\u2010reactive IgA of the total IgA was significantly higher in the GEOP group. These findings indicate an inhibition of total secretory IgA in GEOP, while the <jats:italic>P. gingivalis<\/jats:italic>\u2010reactive humoral immune system in saliva is, however, activated. <jats:italic>P. gingivalis<\/jats:italic> seems to selectively activate IgA lymphocyte clones and induces a switch in the fraction of specific IgA.<\/jats:p>","DOI":"10.1034\/j.1600-0722.2000.00743.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T19:43:59Z","timestamp":1047411839000},"page":"147-153","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Total IgA and <i>Porphyromonas gingivalis<\/i>\u2010reactive IgA in the saliva of patients with generalised early\u2010onset periodontitis"],"prefix":"10.1111","volume":"108","author":[{"given":"Stefan","family":"H\u00e4gewald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pierre","family":"Bernimoulin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eckart","family":"K\u00f6ttgen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Kage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"container-title":["European Journal of Oral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0722.2000.00743.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0722.2000.00743.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0722.2000.00743.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T15:17:56Z","timestamp":1698592676000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0722.2000.00743.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["10.1034\/j.1600-0722.2000.00743.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0722.2000.00743.x","archive":["Portico"],"relation":{},"ISSN":["0909-8836","1600-0722"],"issn-type":[{"value":"0909-8836","type":"print"},{"value":"1600-0722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,4]]},"assertion":[{"value":"2001-12-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}