{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:48:50Z","timestamp":1789505330296,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,12,21]],"date-time":"2001-12-21T00:00:00Z","timestamp":1008892800000},"content-version":"vor","delay-in-days":142,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:p>Native and recombinant human bone morphogenetic\/osteogenic proteins (BMPs\/OPs) singly initiate bone induction <jats:italic>in vivo<\/jats:italic>. The finding of synchronous but spatially different BMPs\/OPs expression during periodontal tissue morphogenesis suggests novel therapeutic approaches using morphogen combinations based on recapitulation of embryonic development. Twelve furcation defects prepared in the first and second mandibular molars of three adult baboons (<jats:italic>Papio ursinus<\/jats:italic>) were used to assess whether qualitative histological aspects of periodontal tissue regeneration could be enhanced and tissue morphogenesis modified by combined or single applications of recombinant hOP\u20101 and hBMP\u20102. Doses of BMPs\/OPs were 100\u2003\u00b5g of each protein per 1\u2003g of insoluble collagenous bone matrix as carrier. Approximately 200\u2003mg of carrier matrix was used per furcation defect. Undecalcified sections cut for histological analysis 60\u2003d after healing of hOP\u20101\u2010treated specimens showed substantial cementogenesis with scattered remnants of the collagenous carrier. hBMP\u20102 applied alone induced greater amounts of mineralized bone and osteoid when compared to hOP\u20101 alone or to combined morphogen applications. Combined applications of hOP\u20101 and hBMP\u20102 did not enhance alveolar bone regeneration or new attachment formation over and above the single applications of the morphogens. The results of this study, which is the first to attempt to address the structure\u2010activity relationship amongst BMP\/OP family members, indicate that tissue morphogenesis induced by hOP\u20101 and hBMP\u20102 is qualitatively different when the morphogens are applied singly, with hOP\u20101 inducing substantial cementogenesis. hBMP\u20102 treated defects, on the other hand, showed limited cementum formation but a temporal enhancement of alveolar bone regeneration and remodelling. The demonstration of therapeutic mosaicism in periodontal regeneration will require extensive testing of ratios and doses of recombinant morphogen combinations for optimal tissue engineering in clinical contexts.<\/jats:p>","DOI":"10.1034\/j.1600-0722.2001.00041.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T19:46:08Z","timestamp":1047411968000},"page":"241-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Periodontal tissue regeneration by combined applications of recombinant human osteogenic protein\u20101 and bone morphogenetic protein\u20102. 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