{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:20:42Z","timestamp":1790918442283,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,11,19]],"date-time":"2002-11-19T00:00:00Z","timestamp":1037664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p>Although the connective tissues of the periodontium are subject to a high turnover rate, no conclusive evidence has yet emerged that periodontal collagen turnover is essential for the eruption of teeth or for root elongation. These processes were studied in mice deficient in MT1\u2010MMP, a membrane type matrix metalloproteinase essential for remodeling of soft tissue\u2013hard tissue interfaces. Mandibular first molars of deficient mice and their wild\u2010type littermates were subjected to stereological analysis in order to assess root length, eruption and the volume density of phagocytosed collagen in periodontal ligament fibroblasts. The data showed that both eruption and root elongation were severely inhibited in animals lacking the enzyme. We also found, in periodontal ligament fibroblasts from MT1\u2010MMP\u2010deficient mice, a massive age\u2010related accumulation (up to 60\u2010fold over controls) of collagen fibril\u2010containing phagosomes. Phagolysosomes, which represent the next downstream step in collagen fibril degradation by the lysosomal pathway, did not accumulate. These observations indicate that MT1\u2010MMP plays a central role in periodontal remodeling. The stunted root growth and the failure to erupt indicate the important role of the enzyme in tooth development.<\/jats:p>","DOI":"10.1034\/j.1600-0722.2002.21384.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T19:47:15Z","timestamp":1047412035000},"page":"445-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["On the role of MT1\u2010MMP, a matrix metalloproteinase essential to collagen remodeling, in murine molar eruption and root growth"],"prefix":"10.1034","volume":"110","author":[{"given":"Wouter","family":"Beertsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenn","family":"Holmbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneke","family":"Niehof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bianco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaliiopi","family":"Chrysovergis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Birkedal\u2010Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Everts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,11,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(97)00115-9"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790120301"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0221-8747(81)90028-X"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(92)90125-R"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.46.95"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345420210020901"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(77)90095-4"},{"key":"e_1_2_5_9_2","first-page":"1029","article-title":"Collagen metabolism and tooth eruption: the effects of sodium morrhuate infusions on premolar eruption in dogs","volume":"105","author":"Marks SC","year":"1995","journal-title":"Schweiz Monatsschr Zahnmed"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02409011"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80064-1"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091890308"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1995.tb44629.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1600-0714.1987.tb02060.x","article-title":"Regional control by the dental follicle of alterations in alveolar bone metabolism during tooth eruption","volume":"16","author":"Marks SC","year":"1987","journal-title":"J Oral Pathol"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003221200"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0174-173X(85)80021-2"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0934-8832(89)80002-2"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.10.5331"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1971.tb00598.x"}],"container-title":["European Journal of Oral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0722.2002.21384.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0722.2002.21384.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T04:59:47Z","timestamp":1704776387000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0722.2002.21384.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,19]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["10.1034\/j.1600-0722.2002.21384.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0722.2002.21384.x","archive":["Portico"],"relation":{},"ISSN":["0909-8836","1600-0722"],"issn-type":[{"value":"0909-8836","type":"print"},{"value":"1600-0722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11,19]]},"assertion":[{"value":"2002-11-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}