{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:46:14Z","timestamp":1761947174327},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,5,22]],"date-time":"2003-05-22T00:00:00Z","timestamp":1053561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:p>There is evidence that the quantity of antigen load is crucial for the activation of IgA immune responses. In order to investigate the relevance of these findings in aggressive periodontitis, salivary antibody responses were measured during non\u2010surgical and antibiotic treatment. Twenty\u2010one patients with generalized aggressive periodontitis were monitored for total salivary IgA and IgA reactive to <jats:italic>Porphyromonas gingivalis<\/jats:italic> in resting and stimulated whole saliva. Non\u2010surgical treatment included full\u2010mouth professional tooth cleaning and subgingival scaling and root planing (SRP) under local anesthesia. Patients were recalled at 3\u2003months and 6\u2003months following systemic antibiotic treatment. Non\u2010parametric statistics showed significant improvements in the clinical parameters in all patients. Between baseline and 4\u2003wk following SRP, median concentrations of total IgA decreased both in resting (\u221246%) and in stimulated (\u221233%) saliva. The <jats:italic>P.\u2003gingivalis<\/jats:italic>\u2010specific IgA activity showed a twofold increase at 4\u2003wk after SRP. In addition to these changes, periodontal treatment of aggressive periodontitis did not appear to affect salivary IgA, and there were no significant correlations of IgA to the clinical parameters. In conclusion, salivary IgA responses during periodontal treatment were not found to have a diagnostic or prognostic significance.<\/jats:p>","DOI":"10.1034\/j.1600-0722.2003.00040.x","type":"journal-article","created":{"date-parts":[[2003,5,22]],"date-time":"2003-05-22T12:31:14Z","timestamp":1053606674000},"page":"203-208","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Salivary IgA in response to periodontal treatment"],"prefix":"10.1111","volume":"111","author":[{"given":"Stefan J.","family":"H\u00e4gewald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel L. W.","family":"Fishel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia E. B.","family":"Christan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pierre","family":"Bernimoulin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Kage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,5,22]]},"reference":[{"key":"e_1_2_15_2_2","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_15_3_2","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.39"},{"key":"e_1_2_15_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1993.tb00216.x"},{"key":"e_1_2_15_5_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1985.56.11s.75"},{"key":"e_1_2_15_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1993.tb00708.x"},{"key":"e_1_2_15_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1995.tb01254.x"},{"key":"e_1_2_15_8_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1987.58.5.314"},{"key":"e_1_2_15_9_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.12.781"},{"key":"e_1_2_15_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1994.tb00281.x"},{"key":"e_1_2_15_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.00013.x"},{"key":"e_1_2_15_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1997.tb00218.x"},{"key":"e_1_2_15_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2000.00743.x"},{"key":"e_1_2_15_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.62.1.71-109.1998"},{"key":"e_1_2_15_15_2","volume-title":"Mucosal immunology","author":"Ogra PLMJ","year":"1998"},{"key":"e_1_2_15_16_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012241117984"},{"key":"e_1_2_15_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/417552a"},{"key":"e_1_2_15_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5474.2222"},{"key":"e_1_2_15_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/89775"},{"key":"e_1_2_15_20_2","first-page":"87","article-title":"Salivary IgA antibody in periodontal diseases: a case\u2010control study","volume":"2","author":"Wang HYEJ","year":"1992","journal-title":"Immunol Infect Dis"},{"key":"e_1_2_15_21_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.3.205"},{"key":"e_1_2_15_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1997.tb00052.x"},{"key":"e_1_2_15_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1998.tb00716.x"},{"key":"e_1_2_15_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.6.762"},{"key":"e_1_2_15_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-8986.3850836"},{"key":"e_1_2_15_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.4.1992-2000.1999"},{"key":"e_1_2_15_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.2.430-445.2001"},{"key":"e_1_2_15_28_2","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2001.6.1.30"},{"key":"e_1_2_15_29_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302X.2001.160604.x"},{"key":"e_1_2_15_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/10454411010120020701"},{"key":"e_1_2_15_31_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1984.55.1.9"},{"key":"e_1_2_15_32_2","first-page":"196","article-title":"Specific antibodies against Actinobacillus actinomycetemcomitans in serum and saliva of patients with advanced periodontitis","volume":"101","author":"Nieminen A","year":"1993","journal-title":"Scand J Dent Res"},{"key":"e_1_2_15_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1996.tb00464.x"},{"key":"e_1_2_15_34_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2001.00360.x"},{"key":"e_1_2_15_35_2","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.2000.1665"},{"key":"e_1_2_15_36_2","doi-asserted-by":"publisher","DOI":"10.1080\/000163501750541174"},{"key":"e_1_2_15_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.9.4318"},{"key":"e_1_2_15_38_2","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.4049\/jimmunol.152.9.4663","article-title":"Oral tolerance in humans: T cell but not B cell tolerance after antigen feeding","volume":"152","author":"Husby S","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_15_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.12.4363-4370.1991"},{"key":"e_1_2_15_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1998.tb00708.x"},{"key":"e_1_2_15_41_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027001030.x"},{"key":"e_1_2_15_42_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028007597.x"},{"key":"e_1_2_15_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1991.tb00505.x"},{"key":"e_1_2_15_44_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00819.x"},{"key":"e_1_2_15_45_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027010769.x"},{"key":"e_1_2_15_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.3.1026-1031.1994"},{"key":"e_1_2_15_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1990.tb00236.x"},{"key":"e_1_2_15_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.3.892-896.1994"}],"container-title":["European Journal of Oral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0722.2003.00040.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0722.2003.00040.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0722.2003.00040.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T12:35:33Z","timestamp":1695904533000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0722.2003.00040.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5,22]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["10.1034\/j.1600-0722.2003.00040.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0722.2003.00040.x","archive":["Portico"],"relation":{},"ISSN":["0909-8836","1600-0722"],"issn-type":[{"value":"0909-8836","type":"print"},{"value":"1600-0722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,5,22]]},"assertion":[{"value":"2003-05-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}