{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:43:00Z","timestamp":1791103380744,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":511,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Research"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p> <jats:styled-content>Mi<\/jats:styled-content>crophthalmia\u2010associated t\n\n\t\t\t\t\transcription f \n\n\t\t\t\t\tactor (MITF) is a transcription factor with a basic\u2010helix\u2010loop\u2010helix\u2010leucine zipper (bHLHZip) structure. Mutations of the <jats:italic>MITF<\/jats:italic> gene cause a variety of phenotypes, most notably in pigmented cells, in several species. In humans, haploinsufficiency of MITF causes Waardenburg syndrome type 2, while a dominant\u2010negative mutation causes Tietz syndrome. Four isoforms have been cloned so far: MITF\u2010M is the most abundant and is expressed in neural\u2010crest\u2010derived melanocytes; MITF\u2010A is expressed in various cultured cells including retinal pigment epithelium (RPE) and enriched in RPE of embryonal and developing eyes; MITF\u2010H are expressed in many types of cultured cells and in the heart tissue; MITF\u2010C is expressed in many types of cultured cells, but not in melanocytes. Many growth factor signaling pathways have been implicated for regulation of MITF at both protein and promoter levels. Most notably, Steel factor\/c\u2010Kit signaling pathway was linked to phosphorylation of MITF at Ser73 and Ser409 through activation of MAP kinase and RSK\u20101, respectively. Phosphorylation of MITF is also conducted at Ser298 through GSK3\u03b2, although the signaling pathway for this event still remains to be elucidated. IGF\u20101 and HGF\/SF pathways may merge with the c\u2010Kit signaling pathway. WNT and MSH signaling pathways regulate MITF positively at the promoter level. Endothelins may regulate MITF at the protein and promoter levels. MITF is involved in the differentiation, growth and survival of pigment cells, employing a number of signaling pathways.<\/jats:p>","DOI":"10.1034\/j.1600-0749.2000.130404.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T16:35:33Z","timestamp":1047486933000},"page":"230-240","source":"Crossref","is-referenced-by-count":235,"title":["MITF: A Stream Flowing for Pigment Cells"],"prefix":"10.1111","volume":"13","author":[{"given":"MASAYOSHI","family":"TACHIBANA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"container-title":["Pigment Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0749.2000.130404.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0749.2000.130404.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0749.2000.130404.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T09:13:05Z","timestamp":1698570785000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0749.2000.130404.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["10.1034\/j.1600-0749.2000.130404.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0749.2000.130404.x","archive":["Portico"],"relation":{},"ISSN":["0893-5785","1600-0749"],"issn-type":[{"value":"0893-5785","type":"print"},{"value":"1600-0749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}