{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T10:12:54Z","timestamp":1698660774054},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":389,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Research"],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p>The sequence of the <jats:italic>tyrosinase<\/jats:italic> (<jats:italic>Tyr<\/jats:italic>) gene coding tracts has been obtained for the gorilla (<jats:italic>Gorilla gorilla gorilla<\/jats:italic>). The five exons of the gene were sequenced in three gorillas and in a normally pigmented human. The <jats:italic>tyrosinase<\/jats:italic> gene has been found to be a very conserved locus with a very low substitution rate. Some nucleotide and amino acid differences were found between the gorilla and human <jats:italic>tyrosinase<\/jats:italic> coding sequences. One of the gorillas included in the study is the only known case of albinism in a gorilla (\u2018Snowflake\u2019). Mutations of the <jats:italic>TYR<\/jats:italic> gene lead to Oculocutaneous Albinism type 1 (OCA1), the most common type of albinism in humans (OMIM accession number 203100). The <jats:italic>TYR<\/jats:italic> gene encodes the tyrosinase enzyme (E.C. 1.14.18.1), whose activity was found to be completely lacking in \u2018Snowflake\u2019, indicating that a mutation in the <jats:italic>Tyr<\/jats:italic> gene is the likely cause of his albinism. Nonetheless, no nucleotide changes were detected that could account for the lack of <jats:italic>Tyr<\/jats:italic> product or tyrosinase activity in Snowflake, and explanations of these findings are discussed.<\/jats:p>","DOI":"10.1034\/j.1600-0749.2000.130609.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T16:35:23Z","timestamp":1047486923000},"page":"467-470","source":"Crossref","is-referenced-by-count":8,"title":["The <i>Tyrosinase<\/i> Gene in Gorillas and the Albinism of \u2018Snowflake\u2019"],"prefix":"10.1111","volume":"13","author":[{"given":"ROSA","family":"MART\u00cdNEZ\u2010ARIAS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"COMAS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AIDA","family":"ANDR\u00c9S","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA\u2010TERESA","family":"ABELL\u00d3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XAVIER","family":"DOMINGO\u2010ROURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAUME","family":"BERTRANPETIT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"container-title":["Pigment Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0749.2000.130609.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0749.2000.130609.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0749.2000.130609.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T18:19:00Z","timestamp":1698603540000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0749.2000.130609.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,12]]}},"alternative-id":["10.1034\/j.1600-0749.2000.130609.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0749.2000.130609.x","archive":["Portico"],"relation":{},"ISSN":["0893-5785","1600-0749"],"issn-type":[{"value":"0893-5785","type":"print"},{"value":"1600-0749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,12]]}}}